SRPK1: A Protein Regulator of Cellular Processes (G6732)

Target Name: SRPK1

NCBI ID: G6732

SRPK1

SRPK1: A Protein Regulator of Cellular Processes

SRPK1 (SRPK1 variant 1) is a protein that is expressed in the endoplasmic reticulum (ER) and is involved in the regulation of protein synthesis in the cell. It is a key regulator of the translation of proteins from mRNA to protein and is often targeted by drugs as a potential drug target or biomarker.

SRPK1 has been shown to play a role in a variety of cellular processes, including cell signaling, protein folding, and stress response. It is a key regulator of the translation of proteins that are involved in cell signaling pathways, such as tyrosine kinase signaling, and is also involved in the regulation of protein folding and stability.

SRPK1 has also been shown to play a role in stress response, particularly in the regulation of protein synthesis in response to stress. It is a key regulator of the translation of proteins that are involved in stress response, such as the protein heat shock factor (Hsp70), which helps to protect the cell from damage caused by heat stress.

In addition to its role in cell signaling and stress response, SRSK1 has also been shown to play a role in the regulation of cell cycle progression. It is a key regulator of the translation of proteins that are involved in cell cycle progression, such as the protein p21 (CDK4), which helps to control the movement of cells into theG1 phase of the cell cycle.

SRPK1 has also been shown to play a role in the regulation of protein stability. It is a key regulator of the translation of proteins that are involved in protein stability, such as the protein stability factor (SPF), which helps to protect protein from degradation.

In conclusion, SRSK1 is a protein that is involved in a variety of cellular processes and is a potential drug target or biomarker. Further research is needed to fully understand the role of SRSK1 in cellular processes and to develop effective treatments for diseases that are caused by SRSK1 dysfunction.

Protein Name: SRSF Protein Kinase 1

Functions: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation

The "SRPK1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SRPK1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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