SRSF10: A Potential Drug Target and Biomarker (G10772)

Target Name: SRSF10

NCBI ID: G10772

SRSF10

SRSF10: A Potential Drug Target and Biomarker

Splicing factors are essential proteins that regulate the production of RNA in the cell. Among the various splicing factors, SRSF10 (SR splicing factor 10) is a key regulator of gene expression and has been implicated in a wide range of cellular processes. SRSF10 plays a crucial role in the regulation of splicing efficiency, which is the process by which the cell removes non-coding regions from the RNA produced by splicing and ensures that only the coding regions are included in the final product.

SRSF10 is a protein that contains 119 amino acid residues and has a calculated molecular weight of 13.9 kDa. It is a single-stranded protein that is expressed in various cell types, including human tissues and organisms. SRSF10 is highly conserved across different species, which indicates that it has a conserved function in different organisms.

SRSF10 has been shown to play a critical role in the regulation of splicing efficiency in various cell types. For example, studies have shown that SRSF10 plays a crucial role in regulating the splicing efficiency of the beta-globin gene in human hematopoietic cells. The beta-globin gene is responsible for producing the protein that is responsible for carrying oxygen from the lungs to the rest of the body.

SRSF10 has also been shown to play a critical role in the regulation of splicing efficiency in the immune system. The immune system is responsible for protecting the body against external threats, including viruses and bacteria. SRSF10 has been shown to regulate the production of antibodies, which are proteins that are produced by the immune system in response to an infection.

In addition to its role in splicing regulation, SRSF10 has also been shown to play a critical role in the regulation of gene expression. Studies have shown that SRSF10 can interact with various DNA-binding proteins and can modulate the activity of these proteins. This suggests that SRSF10 plays a critical role in the regulation of gene expression and that it can be a potential drug target.

SRSF10 has also been shown to be involved in the regulation of cellular processes that are important for the development and progression of cancer. Studies have shown that SRSF10 is involved in the regulation of the expression of genes that are important for the development of cancer. For example, SRSF10 has been shown to play a critical role in the regulation of the expression of the gene encoding the tumor suppressor protein p53.

In conclusion, SRSF10 is a protein that has important roles in splicing regulation and gene expression. Its regulation of splicing efficiency and its involvement in the regulation of cellular processes that are important for the development and progression of cancer make it a potential drug target. Further research is needed to fully understand the functions of SRSF10 and to determine its potential as a drug.

Protein Name: Serine And Arginine Rich Splicing Factor 10

Functions: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250)

The "SRSF10 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SRSF10 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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