SRRM4: Potential Drug Target and Regulatory Protein (G84530)

Target Name: SRRM4

NCBI ID: G84530

SRRM4

SRRM4: Potential Drug Target and Regulatory Protein

SRRM4 (KiAA1853) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the superfamily of RNA-binding proteins, known as the KIAA family. This protein has been shown to play a role in a variety of physiological processes in the body, including cell signaling, DNA replication, and gene expression.

One of the key functions of SRRM4 is its role in regulating the cell cycle. It is a component of the G1-specific regulatory complex, which is responsible for regulating the entry of cells into the cell cycle. This complex is composed of a variety of proteins, including SRRM4, which interacts with the protein p21 (also known as the cell division cycle inhibitor p53).

SRRM4 has also been shown to play a role in the regulation of DNA replication. It is a component of the DNA replication machinery, which is responsible for copying the genetic information of the cell to the daughter cells. This machinery is composed of a variety of proteins, including the protein responsible for recognizing the double helix, called DNA polymerase II.

In addition to its role in regulating the cell cycle and DNA replication, SRRM4 has also been shown to play a role in gene expression. It is a binding partner for the protein coding for the enzyme MyB, which is involved in the regulation of various cellular processes, including cell signaling and inflammation.

SRRM4 has also been shown to play a role in the regulation of cell survival. It is a component of the p53-dependent cell survival (PD-CSC) pathway, which is driven by PD-L1 and PD-L4 proteins. This pathway is an important regulator of apoptosis and can affect biological processes such as cell cycle, DNA replication, and cell survival.

In recent years, researchers have studied more and more SRRM4 and found that it is not only related to a variety of diseases, but may also be a potential drug target. First, studies have shown that deletion of SRRM4 leads to increased neuronal apoptosis in mice, thereby increasing the risk of neuronal diseases. In addition, studies have shown that SRRM4 is up-regulated in a variety of cancers and may become a cancer biomarker.

In addition, some studies have also shown that SRRM4 may be related to the expression of PD-L1. PD-L1 is a protein expressed in many tumors that suppresses T cell immune responses. The researchers found that the binding of SRRM4 to PD-L1 leads to increased apoptosis, which may increase the chemotherapy sensitivity of PD-L1-positive tumors.

In addition, some studies have also shown that SRRM4 may be involved in the invasion and metastasis of tumor cells. Studies have shown that SRRM4 is related to the invasion and metastasis of tumor cells and may play an important role in the invasion and metastasis of tumor cells.

In summary, SRRM4 is a protein worthy of attention, with multiple physiological functions and pathological significance. With the deepening of research, SRRM4 may become a new drug target and provide new ideas for the treatment of various diseases.

Protein Name: Serine/arginine Repetitive Matrix 4

Functions: Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells (PubMed:30684677). Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (By similarity)

The "SRRM4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SRRM4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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