SRSF12: A Protein Involved in Gene Expression Regulation and Potential Drug Target

Target Name: SRSF12

NCBI ID: G135295

SRSF12

SRSF12: A Protein Involved in Gene Expression Regulation and Potential Drug Target

Splicing factor 12 (SRSF12) is a protein that plays a critical role in the regulation of gene expression in the cell. It is a 24-kDa protein that is composed of 131 amino acid residues and has a calculated pI of 1.5. SRSF12 is expressed in all cell types and is involved in the regulation of various cellular processes, including cell growth, differentiation, and apoptosis.

One of the unique features of SRSF12 is its ability to recruit specific interacting proteins to its binding site on target genes. This is accomplished through a process called post-translational modification (PTM), which involves the addition or removal of specific amino acid residues to or from a protein after its synthesis. SRSF12 can bind to several different protein substrates, including histone modifications, non-histone modifications, and small molecules.

SRSF12 has been shown to play a role in the regulation of various cellular processes, including cell growth, differentiation, and apoptosis. For example, SRSF12 has been shown to be involved in the regulation of cell cycle progression, by preventing the entry of cells into the G1 phase and promoting the entry of cells into the S phase. SRSF12 has also been shown to play a role in the regulation of cell apoptosis, by preventing the execution of programmed cell death and promoting the execution of unprogrammed cell death.

SRSF12 has also been shown to be involved in the regulation of protein translation, by interacting with various factors involved in the translation process, including the factors that initiate and regulate protein translation. SRSF12 has been shown to play a role in the regulation of protein stability , by preventing the degradation of its target proteins and promoting their stability.

SRSF12 has also been shown to be involved in the regulation of cellular signaling pathways, by interacting with various signaling molecules and modulators. SRSF12 has also been shown to play a role in the regulation of theNotch signaling pathway, by interacting with the protein Notch and promoting the Notch-dependent signaling pathway.

SRSF12 has also been shown to be involved in the regulation of cellular immune response, by interacting with various immune molecules and modulators. SRSF12 has also been shown to play a role in the regulation of the immune response, by interacting with the protein PD-L1 and promoting the immune response.

In conclusion, SRSF12 is a protein that plays a critical role in the regulation of gene expression in the cell. Its ability to recruit specific interacting proteins to its binding site on target genes makes it an attractive drug target and a potential biomarker for various diseases. Further research is needed to fully understand the role of SRSF12 in the regulation of cellular processes and its potential as a drug target.

Protein Name: Serine And Arginine Rich Splicing Factor 12

Functions: Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation

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•   general information;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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