SSX2IP: A Protein Targeted for Drug Development in Diseases (G117178)

Target Name: SSX2IP

NCBI ID: G117178

SSX2IP

SSX2IP: A Protein Targeted for Drug Development in Diseases

SSX2IP (short for short for hydrophobic/hydrophilic interaction domain) is a protein that is located in the endoplasmic reticulum (ER) and plays a crucial role in the regulation of protein stability and localization. The ER is a membrane system, Produced by the Golgi apparatus, it is responsible for modifying, sorting, and packaging proteins from ribosomes and directing them to the cell membrane or other extracellular structures. Under normal circumstances, SSX2IP modifies proteins by binding to other proteins, thereby affecting their localization, stability and functions. However, in certain diseases, the functional imbalance of SSX2IP may lead to abnormal localization of proteins, thereby damaging cells. cause adverse effects.

As a drug target (or biomarker), SSX2IP has been extensively studied as a potential drug for the treatment of many diseases. First, in cancer, abnormal localization of SSX2IP may lead to the evasion of immune surveillance by tumor cells, thereby increasing the survival rate of tumor cells. Secondly, in neurological diseases, abnormal localization of SSX2IP may lead to abnormal synapse formation in nerve cells, thus exacerbating neurodegenerative diseases. Furthermore, in cardiovascular diseases, abnormal localization of SSX2IP may lead to abnormal function of cardiomyocytes, thereby increasing the risk of myocardial infarction.

In addition, SSX2IP also interacts with many drugs, and these interactions may affect the localization, stability and functions of SSX2IP. For example, antihypertensive drugs, such as benazepril and eplerenone, can bind to SSX2IP, affecting its localization and stability. In addition, antidepressant drugs, such as fluoxetine and paroxetine, can also affect the localization of SSX2IP, thereby increasing symptoms in patients with depression.

In addition, some studies have shown that localization of SSX2IP may be related to the incidence of certain diseases. For example, some studies have found that abnormal SSX2IP localization is positively associated with the incidence of Parkinson's disease. In addition, some studies have also shown that abnormal SSX2IP localization is positively correlated with the incidence of Alzheimer's disease.

In summary, SSX2IP (hydrophobic/hydrophilic interaction domain) is a protein that plays a key role in protein localization, stability and functions under normal circumstances. In certain diseases, functional imbalance of SSX2IP may lead to abnormal localization of the protein, thereby causing adverse effects on cells. Therefore, SSX2IP deserves in-depth study as a drug target (or biomarker) in order to provide new means for treating various diseases. At the same time, research on the localization mechanism of SSX2IP may also provide new ideas for the development of new anti-disease drugs.

Protein Name: SSX Family Member 2 Interacting Protein

Functions: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449)

The "SSX2IP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SSX2IP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets