UBB: A Protein Involved in Cellular Order and Homeostasis (G7314)

Target Name: UBB

NCBI ID: G7314

Content of Review Report on UBB Target / Biomarker

UBB

UBB: A Protein Involved in Cellular Order and Homeostasis

UBB (polyubiquitin B) is a protein that is expressed in all living cells and is involved in a variety of cellular processes. It is a key player in the ubiquitin system, a protein degradation system that is essential for maintaining cellular order and homeostasis. UBB has been identified as a potential drug target and has the potential to be used as a biomarker for a variety of diseases.

The ubiquitin system is a complex protein degradation system that is involved in the regulation of protein structure, stability, and function. UBB is one of the key proteins that is involved in this system. It is a 21-kDa protein that is composed of a unique sequence of amino acids. UBB is expressed in all living cells and is found in a variety of cellular organelles, including the endoplasmic reticulum, the mitochondria, and the endoplasmic reticulum.

UBB is involved in the degradation of a variety of proteins, including enzymes, sensors, and signaling proteins. It is also involved in the regulation of cellular processes such as cell division, DNA replication, and cell signaling.

One of the key functions of UBB is its role in the degradation of damaged proteins. damaged proteins can accumulate in the endoplasmic reticulum and interfere with the normal function of the ubiquitin system. UBB is involved in the degradation of these damaged proteins, removing them from the endoplasmic reticulum and preventing them from causing cellular stress and dysfunction.

In addition to its role in the ubiquitin system, UBB is also involved in the regulation of cellular signaling pathways. It is a component of several signaling pathways that are involved in cell growth, differentiation, and survival. UBB plays a key role in the regulation of the PI3K/Akt signaling pathway, a pathway that is involved in the regulation of cellular growth and survival.

UBB is also involved in the regulation of cell division. It is a component of the microtubule protein complex, a protein structure that is involved in cell division. UBB helps to regulate the movement of microtubules along the plasma membrane during cell division, ensuring that each new cell that is formed has an accurate number of chromosomes.

In conclusion, UBB is a protein that is involved in a variety of cellular processes that are essential for maintaining cellular order and homeostasis. Its involvement in the ubiquitin system, the regulation of cellular signaling pathways, and the regulation of cell division make it a potential drug target and a valuable biomarker for a variety of diseases.

Protein Name: Ubiquitin B

Functions: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling

The "UBB Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UBB comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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