Understanding The Role of Ubiquitin-C in Cell Signaling and DNA Repair

Target Name: UBC

NCBI ID: G7316

Content of Review Report on UBC Target / Biomarker

UBC

Understanding The Role of Ubiquitin-C in Cell Signaling and DNA Repair

Ubiquitin-C (UBC) is a protein that plays a crucial role in cell signaling and DNA repair. It is a key component of the ubiquitin system, which is a network of proteins that helps to break down and remove damaged or unnecessary proteins from cells . UBC is one of the proteins that makes up this system and has been shown to be involved in a wide range of cellular processes.

One of the key functions of UBC is its role in DNA repair. When DNA is damaged or impaired, the cell's repair system is activated to repair the damage. UBC is involved in this process, as it helps to ensure that the repair process is carried out correctly.

UBC is also involved in cell signaling, particularly in the regulation of cell growth and differentiation. It has been shown to play a role in the development and maintenance of cancer, as well as in the regulation of cell signaling pathways that are involved in both cells growth and differentiation.

In addition to its role in cell signaling and DNA repair, UBC is also involved in the regulation of inflammation. It has been shown to play a key role in the development of inflammatory diseases, as well as in the regulation of the immune system.

Given its involvement in a wide range of cellular processes, UBC has been identified as a potential drug target. Researchers are currently working to develop new treatments for a variety of diseases that are caused by the error or dysfunction of UBC. These treatments are focused on targeting UBC with small molecules, antibodies, or other therapeutic agents in order to correct the problems with UBC that are causing the diseases.

In addition to its potential as a drug target, UBC is also a potential biomarker for a variety of diseases. Its involvement in a wide range of cellular processes makes it an attractive target for researchers who are looking for new diagnostic tools. For example, researchers have used UBC as a biomarker to diagnose and monitor a variety of diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.

Overall, UBC is a protein that has important roles in cell signaling, DNA repair, and inflammation. Its potential as a drug target and biomarker make it an attractive target for researchers who are working to develop new treatments and diagnostic tools for a variety of diseases .

Protein Name: Ubiquitin C

Functions: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling

The "UBC Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UBC comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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