Target Name: ZNF195
NCBI ID: G7748
Review Report on ZNF195 Target / Biomarker Content of Review Report on ZNF195 Target / Biomarker
ZNF195
Other Name(s): krueppel family zinc finger protein (znfp104) | zinc finger protein 195 | Zinc finger protein 195, transcript variant 11 | ZNF195 variant 1 | DKFZp666D035 | Zinc finger protein 195 (isoform 8) | HRF1 | Zinc finger protein 195, transcript variant 1 | hypoxia-regulated factor-1 | ZNF195 variant 11 | ZN195_HUMAN | ZNFP104 | Zinc finger protein 195 (isoform 1) | Zinc finger protein 195

ZNF195: A promising drug target and biomarker for treating zinc deficiency and other disorders

Zinc (Zn) is a crucial mineral that plays a vital role in various cellular processes. It is involved in over 300 cellular signaling pathways and has been implicated in numerous diseases, including cancer, neurodegenerative diseases, and reproductive disorders. ZNF195, a member of the krueppel family zinc finger protein (ZNF) family, has been identified as a promising drug target and biomarker for treating zinc deficiency and other disorders.

ZNF195 function and localization

ZNF195 is a 21-kDa protein that belongs to the ZNF family of zinc fingers. It consists of four conserved domains: a N-terminal zinc finger, a C-terminal DNA-binding domain, a T-loop domain, and a variable C-terminal region. ZNF195 is expressed in various tissues and cells, including liver, muscle, heart, kidney, and brain. It is primarily localized to the nuclear matrix, where it can interact with various nuclear proteins, including histone modifications and non-histone modifications.

ZNF195 functions as a zinc finger protein

ZNF195 functions as a zinc finger protein by forming a complex with nuclear proteins, including histone modifications and non-histone modifications. Histone modifications are important for the regulation of gene expression and play a crucial role in cellular processes, such as cell growth, differentiation, and stress resistance. Non-histone modifications, such as histone deacetylation (HDACs) and histone methylation (HM), also impact gene expression and contribute to the regulation of cellular processes.

The N-terminal zinc finger domain of ZNF195 contains a zinc finger core that can interact with various zinc ions, which are essential for various cellular processes, including DNA replication, transcription, and translation. The C-terminal domain contains a zinc-binding loop and a T-loop domain that can interact with the zinc ion. The T-loop domain is important for the formation of a nucleosome, which is the basic unit of the chromatin.

ZNF195 is involved in various cellular processes

ZNF195 is involved in various cellular processes, including DNA replication, transcription, and translation. It has been shown to play a role in the regulation of gene expression and in the regulation of DNA replication, transcription, and translation. ZNF195 has also been shown to interact with various nuclear proteins, including histone modifications and non-histone modifications.

In addition to its role in cellular processes, ZNF195 has also been shown to play a role in diseases. ZNF195 has been implicated in various diseases, including cancer, neurodegenerative diseases, and reproductive disorders. ZNF195 has also been shown to be involved in the regulation of cellular processes that are associated with aging, such as DNA damage repair, and has been shown to play a role in the regulation of cellular processes that are associated with stress, such as stress signaling.

Drug targeting ZNF195

The potential of ZNF195 as a drug target is due to its unique function and localization in the cell. ZNF195 is primarily localized to the nuclear matrix, where it can interact with various nuclear proteins, including histone modifications and non-histone modifications. This creates an opportunity to target ZNF195 directly and disrupt its function in the nucleus.

One approach to targeting ZNF195 is to use small molecules that can modulate its activity in the nucleus.

Protein Name: Zinc Finger Protein 195

Functions: May be involved in transcriptional regulation

The "ZNF195 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF195 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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