TTPAL: A novel protein Target for Drug Development (G79183)

Target Name: TTPAL

NCBI ID: G79183

TTPAL

TTPAL: A novel protein Target for Drug Development

TTPAL (Transcript Variant 1), also known as Alpha-Tocopherol Transfer Protein Like, is a protein that plays a crucial role in the transport of tocopherol (vitamin E) from the gut to the liver. It is a key mediator in the vitamin E homeostasis and has been implicated in various diseases, including cardiovascular, neurodegenerative, and liver diseases. The identification of TTPAL as a potential drug target has significant implications for the development of new therapeutic approaches.

Background

Tcopherol is a fat-soluble vitamin that is essential for maintaining cellular health and preventing oxidative stress. It is one of the eight essential vitamins that the human body cannot produce on its own and must be obtained through dietary sources or supplements. Tcopherol is a major antioxidant that functions as a free radical scavenger, protecting cells from damage caused by reactive oxygen species.

Natural Occurrence

TTPAL is naturally occurring in various organisms, including humans. It is expressed in various tissues, including the liver, where it is primarily synthesized and secreted. Ttpal has also been identified in tissues of interest, such as the kidneys, heart, and brain.

Function

TTPAL is a transmembrane protein that plays a key role in the transport of tocopherol across the intestinal wall and into the bloodstream. It is a six-transmembrane protein that consists of an extracellular region, a transmembrane region, and an intracellular region. The extracellular region contains a N-terminus that is involved in the formation of a complex with various proteins, including the E-cadherin protein, which is known to play a role in the transport of tocopherol across the intestinal wall.

The transmembrane region of TTPAL is characterized by the presence of multiple transmembrane domains, including an N-terminal alpha-helices and a C-terminal T-spike. The alpha-helices are involved in the formation of the transmembrane region and are known to play a role in the stability and localization of the protein. The C-terminal T-spike is involved in the formation of the protein-protein interaction and is known to play a role in the regulation of cellular signaling pathways.

TTPAL functions as a receptor for various signaling pathways, including the T cell-mediated signaling pathway. It has been shown to play a role in the regulation of cellular signaling pathways, including the T cell-mediated signaling pathway.

Mutations in TTPAL

Mutations in TTPAL have been observed that can affect its function and contribute to various diseases. The most well-known mutation is the missense mutation, which results in the substitution of the amino acid Asp for Asn at position 298. This mutation has been shown to have a significant impact on the structure and function of TTPAL.

Drug Development

The identification of TTPAL as a potential drug target has significant implications for the development of new therapeutic approaches. Drugs that target TTPAL have the potential to treat various diseases, including cardiovascular, neurodegenerative, and liver diseases.

One approach to targeting TTPAL is the use of small molecules that can modulate its function. Many small molecules have been shown to interact with TTPAL and have the potential to act as modulators. One such small molecule is called 1,2-dimethylpropionitrile (DMP), which is a derivative of salicylate, a natural compound that has been shown to have various biological effects.

Another approach to targeting TTPAL is the use of antibodies that can selectively bind to the protein and trigger downstream signaling pathways. Monoclonal antibodies (MCAs) have been shown to be effective in targeting TTPAL and have the potential to treat various diseases.

Conclusion

In conclusion, TTPAL is a protein that plays a crucial role in the transport of tocopherol across the intestinal wall and into the bloodstream. Its function as a receptor for various signaling pathways makes it an attractive target for drug development. The identification of TTPAL as a potential drug target has significant implications for the development of new therapeutic approaches that can treat various diseases. Further research is needed to fully understand the role of TTPAL as a drug target and to develop effective therapies that can target this protein.

Protein Name: Alpha Tocopherol Transfer Protein Like

Functions: May act as a protein that binds a hydrophobic ligand

The "TTPAL Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TTPAL comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets