C1orf115: A Potential Drug Target and Biomarker for Chromosome 1 Open Reading Frame 115

Target Name: C1orf115

NCBI ID: G79762

C1orf115

C1orf115: A Potential Drug Target and Biomarker for Chromosome 1 Open Reading Frame 115

Introduction

Chromosome 1 (1p) is one of the most highly conserved regions in the human genome, which contributes to its role as a key regulator of cell identity, development, and progression. Open reading frame (ORF) 115, located on the long arm of chromosome 1, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. In this article, we will explore the biology and potential therapeutic applications of C1orf115.

The Chromosome 1 Open Reading Frame 115

The ORF is a genomic region that contains the majority of the coding sequence for a gene within a chromosome. ORFs are often involved in the regulation of gene expression, as they can encode functional domains that interact with other proteins to influence cellular behavior. ORFs can also serve as potential drug targets due to their unique structure and the presence of various post-translational modifications (PTMs), such as phosphorylation, ubiquitination, and cleavage by enzymes.

C1orf115, located on the long arm of chromosome 1 at position 6148 deletions, is a highly conserved gene that encodes a protein named MADH1 (MutL homolog 1). MADH1 is a member of the MADH family of proteins, which are involved in the regulation of mitochondrial function and dynamics. MADH1 has been implicated in various cellular processes, including DNA replication, gene expression, and stress response.

Expression and Functions of MADH1

MADH1 is a key regulator of mitochondrial dynamics and function, and its expression is highly dependent on factors such as DNA replication, cell cycle progression, and stress response. MADH1 has been shown to play a critical role in the regulation of mitochondrial DNA replication, with MADH1-null mice experience increased mitochondrial DNA damage and impaired cellular proliferation compared to wild-type animals.

In addition to its role in regulating mitochondrial function, MADH1 has also been implicated in the regulation of cellular stress responses. MADH1 has been shown to interact with various stress-responsive transcription factors, including ATF-2, activating transcription factor 3 (ATF-3 ), and HDAX. MADH1-null mice have increased sensitivity to oxidative stress, suggesting that MADH1 may serve as a negative regulator of cellular stress responses.

C1orf115 as a Potential Drug Target

The potential therapeutic applications of C1orf115 arise from its involvement in the regulation of mitochondrial function and dynamics. MADH1 has been shown to play a critical role in the regulation of cellular processes that are relevant to a variety of diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. Therefore, C1orf115 may be a promising drug target for the treatment of these diseases.

C1orf115 has been selected as a potential drug target due to its unique expression and the presence of various PTMs. MADH1 has been shown to have a highly conserved N-terminus, which suggests that it may be a good target for small molecules. In addition, MADH1 is a protein that is predominantly expressed in the brain, making it an attractive target for the treatment of psychiatric disorders.

C1orf115 has also been shown to play a critical role in the regulation of cellular stress responses, which may be relevant to the treatment of neurodegenerative diseases. MADH1 has also been shown to interact with various stress-responsive transcription factors, including

Protein Name: Chromosome 1 Open Reading Frame 115

Functions: Regulates drug efflux through modulation of ABCB1 localization and activity

The "C1orf115 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about C1orf115 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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