H4: A Protein Involved in Chromatin Structure and Gene Expression

Target Name: H4C8

NCBI ID: G8365

H4C8

Other Name(s): histone cluster 1 H4 family member h | histone cluster 1, H4h | Histone H4 | H4C14 | HIST1H4H | H4 clustered histone 8 | translation initiation factor IF-2-like | H4FH | H4_HUMAN | H4C12 | histone 1, H4h | H4C11 | H4C9 | H4/H | H4C5 | H4/h | H4C6 | H4C16 | H4C15 | H4C3 | H4C1 | H4 histone family, member H | H4C4 | H4C13 | H4C2 | H4-16

H4: A Protein Involved in Chromatin Structure and Gene Expression

Histone cluster 1 (H4) is a family of proteins that play a critical role in the regulation of gene expression and chromosomal stability. H4 is a transmembrane protein that consists of four histone domains: H1, H2, H3, and H4. H4 is highly conserved across different species, and its only function is to form a histone complex, which is a core component of the nucleosome.

The H4 family member H4 (H4) is a protein that is expressed in almost all cell types and is involved in the regulation of gene expression and chromatin structure. It is a key player in the histone cluster 1 (H4) complex, which is a network of histone domains that work together to regulate chromatin stability and transcription.

H4 is a 20-kDa protein that consists of four histone domains: H1, H2, H3, and H4. The H1 domain is the N-terminus of the protein and is responsible for its transmembrane properties. The H2 domain is the C-terminus of the protein and is involved in the formation of the histone complex. The H3 domain is the middle domain of the protein and is responsible for the formation of the nucleosome. The H4 domain is the C-terminus of the protein and is involved in the formation of the histone complex.

H4 is involved in the regulation of gene expression by binding to specific DNA sequences. It has been shown to play a role in the regulation of gene expression in various organisms, including humans. For example, studies have shown that H4 can interact with the transcription factor p53 and that it can modulate the activity of the p21 regulatory protein, which is involved in the regulation of cell cycle progression and apoptosis.

H4 is also involved in the regulation of chromatin structure and stability. It has been shown to interact with the histone variant H2B and that it can modulate the activity of the histone-remodeling enzyme HIRC. This enzyme is responsible for the removal of histone tails, which is important for the regulation of chromatin stability.

H4 is a potential drug target for various diseases, including cancer. Its involvement in the regulation of gene expression and chromatin structure makes it an attractive target for small molecules that can modulate its activity. Additionally, its conserved nature across different species makes it a good candidate for biomarkers that can be used to diagnose and monitor disease.

In conclusion, H4 is a key player in the regulation of gene expression and chromatin structure. Its involvement in the histone cluster 1 complex and its potential as a drug target make it an attractive target for small molecules that can modulate its activity. Further research is needed to fully understand its role in the regulation of gene expression and chromatin structure and to develop effective treatments for diseases that are dependent on its function.

Protein Name: H4 Clustered Histone 8

Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

The "H4C8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about H4C8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets