Targeting FHIP1B: Potential Drug or Biomarker for Cancer Therapies

Target Name: FHIP1B

NCBI ID: G84067

FHIP1B

Targeting FHIP1B: Potential Drug or Biomarker for Cancer Therapies

FHF complex subunit HOOK interacting protein 1B (FHIP1B), also known as transcribed assembly factor 1B (TAF1B), is a protein that plays a critical role in the regulation of cell growth, differentiation, and survival. It is a member of the FHF complex, a protein-protein interaction network that is involved in various cellular processes, including cell adhesion, migration, and signaling. FHIP1B is expressed in various tissues and cells and is known to interact with various protein partners, including the transcription factor TAF1A2.

Drug targeting

FHIP1B is a potential drug target due to its involvement in various cellular processes that are crucial for cancer progression. Several studies have suggested that inhibition of FHIP1B could be an effective way to treat various types of cancer, including breast, ovarian, and colorectal cancers.

One of the reasons for the potential of FHIP1B as a drug target is its involvement in the regulation of cell adhesion and migration. FHIP1B is a critical regulator of tight cell-cell adhesion and has been shown to play a role in the regulation of cell migration. Several studies have shown that FHIP1B is involved in the regulation of cell migration and that inhibition of its activity can inhibit the migration of cancer cells.

Another potential mechanism by which FHIP1B may be targeted as a drug is its role in cell signaling. FHIP1B is a key regulator of the FHF complex, which is involved in various signaling pathways, including the regulation of cell growth, differentiation, and survival. Several studies have shown that FHIP1B is involved in the regulation of cell signaling and that inhibition of its activity can inhibit the signaling pathways that promote cancer growth.

Biomarker

FHIP1B may also be used as a biomarker for cancer diagnosis and treatment. Since FHIP1B is expressed in various tissues and cells, it may be used as a marker for the presence of cancer cells in the body. Several studies have shown that FHIP1B is expressed in various types of cancer, including breast, ovarian, and colorectal cancers. Therefore, FHIP1B may be used as a biomarker for the diagnosis and treatment of these cancers.

Targeting FHIP1B

Currently, there are several ongoing studies aimed at targeting FHIP1B as a potential drug or biomarker. One of the most promising strategies is the use of small molecules, such as inhibitors, to inhibit the activity of FHIP1B. Several studies have shown that inhibitors of FHIP1B have the potential to inhibit the activity of FHIP1B and its downstream targets, including the transcription factor TAF1A2.

Another approach to targeting FHIP1B is the use of antibodies that are designed to specifically recognize and bind to FHIP1B. Several studies have shown that antibodies against FHIP1B have the potential to selectively bind to FHIP1B and inhibit its activity. These antibodies may be used to target FHIP1B directly and can also be used to monitor the activity of FHIP1B in cells.

Conclusion

FHF complex subunit HOOK interacting protein 1B (FHIP1B) is a protein that plays a critical role in the regulation of cell growth, differentiation, and survival. Its potential as a drug target or biomarker makes it an attractive target for the development of new cancer therapies. Currently, several studies are aimed at targeting FHIP1B and its downstream targets, including the transcription factor TAF1A2, using small molecules and antibodies. Further studies are needed to determine the effectiveness of these approaches and to develop new strategies for the targeted inhibition of FHIP1B.

Protein Name: FHF Complex Subunit HOOK Interacting Protein 1B

Functions: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997)

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•   general information;
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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