FGFRI: A Protein Involved in Tissue Development and Maintenance

Target Name: FGFR1

NCBI ID: G2260

FGFR1

FGFRI: A Protein Involved in Tissue Development and Maintenance

FGFRI (FGF-R1) is a protein that is expressed in various tissues throughout the body, including the skin, hair, nails, and bones. It is a member of the FGF receptor family, which is a group of transmembrane proteins that are involved in cell-to-cell signaling. One of the functions of FGFRI is to regulate the growth and differentiation of cells, and it is often used as a drug target or biomarker for various diseases.

FGFRI has been shown to play a role in a number of biological processes, including cell proliferation, differentiation, and angiogenesis. It is involved in the development and maintenance of tissues, such as the skin and hair, and it is also involved in the regulation of cellular processes that are important for tissue growth and repair.

One of the unique features of FGFRI is its ability to interact with a variety of different proteins, including FGFR2, which is a protein that is involved in the development and maintenance of tissues. FGFRI and FGFR2 can interact with each other to regulate cellular processes that are important for tissue development and maintenance.

FGFRI has also been shown to be involved in the regulation of cellular processes that are important for the development and maintenance of cancer. It is often used as a drug target or biomarker for cancer, as it has been shown to play a role in the development and progression of a variety of different types of cancer.

In addition to its role in cancer, FGFRI is also involved in the regulation of cellular processes that are important for the development and maintenance of diseases of the skin and hair. It is often used as a drug target or biomarker for conditions such as dystrophia, a genetic disorder that is characterized by the progressive loss of muscle mass and strength, and alopecia, a condition that is characterized by the loss of hair.

FGFRI is also being studied as a potential biomarker for other diseases, including heart disease and neurodegenerative diseases. It is involved in the development and maintenance of tissues, and it is often used as a drug target or biomarker for conditions that are characterized by the progressive loss of tissues or the progressive decline in cellular processes.

In conclusion, FGFRI is a protein that is expressed in various tissues throughout the body and is involved in a variety of biological processes. It is a member of the FGF receptor family and has been shown to play a role in the development and maintenance of tissues, as well as in the regulation of cellular processes that are important for the development and maintenance of diseases. FGFRI is currently being studied as a potential drug target or biomarker for various diseases, including cancer, dystrophia, alopecia, and other conditions characterized by the progressive loss of tissues or the progressive decline in cellular processes.

Protein Name: Fibroblast Growth Factor Receptor 1

Functions: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation

The "FGFR1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FGFR1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets