GINS4: A Potential Drug Target for Diseases (G84296)

Target Name: GINS4

NCBI ID: G84296

GINS4

GINS4: A Potential Drug Target for Diseases

GINS4, also known as GINS complex subunit 4, is a protein that is expressed in various tissues and cells in the human body. It is a key component of the GINS gene family, which encodes a family of transmembrane proteins that play a critical role in intracellular signaling. GINS4 is one of the four subunits of the GINS complex, which is a protein complex that is involved in the regulation of various cellular processes, including cell signaling, DNA replication, and metabolism.

The GINS gene family has been identified as a potential drug target in the development of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. GINS4 has been shown to be involved in several cellular processes that are linked to the development and progression of these diseases, which makes it an attractive target for researchers to investigate.

One of the key functions of GINS4 is its role in cell signaling. GINS4 is a critical subunit of the protein S/TIM-2, which is a complex that is involved in the regulation of T cell signaling. GINS4 plays a key role in the regulation of the activity of T cells, which are a crucial immune cell that play a critical role in fighting off infections and diseases.

In neurodegenerative diseases, GINS4 has also been shown to be involved in the regulation of neurotransmitter signaling, which is important for the proper functioning of neuronal cells. GINS4 has also been shown to be involved in the regulation of cell cycle progression, which is important for the growth and development of neurons.

In addition to its role in cell signaling, GINS4 is also involved in the regulation of DNA replication. GINS4 has been shown to be a critical subunit of the DNA replication machinery, which is responsible for copying the genetic material of a cell to create a new one.

GINS4 has also been shown to be involved in the regulation of metabolism. GINS4 plays a key role in the regulation of the activity of enzymes that are involved in metabolism, including the citrate cycle and the glycolytic pathway.

GINS4 is also a potential biomarker for several diseases, including cancer. GINS4 has been shown to be expressed in various types of cancer, including breast, ovarian, and prostate cancer. Additionally, GINS4 has been shown to be involved in the regulation of cancer cell growth and metastasis, which could be an attractive target for cancer therapies.

In conclusion, GINS4 is a protein that is expressed in various tissues and cells in the human body. It is a key component of the GINS gene family, which encodes a family of transmembrane proteins that play a critical role in intracellular signaling. GINS4 is involved in several cellular processes that are linked to the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a potential drug target and biomarker, GINS4 is an attractive target for researchers to investigate and develop new therapies for these diseases .

Protein Name: GINS Complex Subunit 4

Functions: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232)

The "GINS4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GINS4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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