HRAS GTPase: Potential Drug Targets (G3265)

Target Name: HRAS

NCBI ID: G3265

HRAS

HRAS GTPase: Potential Drug Targets

HRAS (HRas proto-oncogene, GTPase, transcript variant 2) is a gene that encodes a protein known as HRAS GTPase, which plays a critical role in cell signaling pathways. The HRAS gene has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. However, despite its significant impact on human health, the precise function and regulation of HRAS GTPase remain poorly understood.

During the past few years, researchers have made significant progress in the study of HRAS GTPase and its potential as a drug target. In this article, we will provide an overview of HRAS GTPase, its functions, and potential as a drug target.

FUNCTION OF HRAS GTPASE
HRAS GTPase is a protein that plays a vital role in cell signaling pathways. It functions as a GTPase, which means it canGDPs (Guanosine Triphosphate) and GDPs (Guanosine Diphosphate) to regulate protein-protein interactions and signaling pathways. GTPases are a family of transmembrane proteins that play a central role in various cellular processes, including cell signaling, cytoskeletal organization, and intracellular transport.

HRAS GTPase is involved in several critical signaling pathways, including theMAPK/ERK signaling pathway, the PI3K/AKT signaling pathway, and the TGF-β signaling pathway. It is also involved in the regulation of cell adhesion, migration, and invasion. Additionally, HRAS GTPase is involved in the regulation of cell cycle progression, apoptosis, and stress resistance.

POTENTIAL AS A DRUG TARGET
TheHRas GTPase has been identified as a potential drug target due to its involvement in various diseases. Several studies have shown that HRAS GTPase is overexpressed or mutated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

HRAS GTPase has been shown to be involved in the regulation of cancer cell growth, invasion, and metastasis. For example, studies have shown that HRAS GTPase is involved in the regulation of the growth and survival of human cancer cells. Additionally, HRAS GTPase has been shown to play a role in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

HRAS GTPase has also been shown to be involved in the regulation of developmental disorders, including Down syndrome and Fragile X syndrome. These studies suggest that HRAS GTPase may be a useful drug target for the treatment of various diseases.

IMPACT OF HRAS GTPASE ON HUMAN HEALTH
TheHRas GTPase is involved in many critical processes that are essential for human health. However, the precise function and regulation of HRAS GTPase remain poorly understood. Further research is needed to determine the exact role of HRAS GTPase in human health and to develop effective treatments for diseases associated with its dysfunction.

Conclusion
HRAS GTPase is a protein that plays a critical role in cell signaling pathways. Its functions include regulating protein-protein interactions and signaling pathways, as well as involved in the regulation of cell adhesion, migration, and invasion. TheHRas GTPase gene has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Further research is needed to determine the exact role of HRAS GTPase in human health and to develop effective treatments for its dysfunction.

Protein Name: HRas Proto-oncogene, GTPase

Functions: Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151)

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