HPGD: Key Enzyme in Plant Plastidial Electron Transport Chain

Target Name: HPGD

NCBI ID: G3248

HPGD

HPGD: Key Enzyme in Plant Plastidial Electron Transport Chain

Hetero-Plastidium Generator (HPGD) is a protein that belongs to the Short Chain Dehydrogenase/Reductase Family 36C. It is a key enzyme in the plastidial electron transport chain, which is a critical pathway for energy production in plant cells. HPGD is responsible for

Protein Name: 15-hydroxyprostaglandin Dehydrogenase

Functions: Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (PubMed:8086429, PubMed:10837478, PubMed:16828555, PubMed:16757471, PubMed:21916491, PubMed:25586183). Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression (PubMed:25586183, PubMed:15574495). Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (PubMed:16757471, PubMed:22844113)

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•   general information;
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