HOXD-AS2: A Promising Drug Target / Biomarker (G100506783)

Target Name: HOXD-AS2

NCBI ID: G100506783

HOXD-AS2

Other Name(s): HOXD cluster antisense RNA 2

HOXD-AS2: A Promising Drug Target / Biomarker

Hoxd-AS2 (Hoxd-As2) is a protein that is expressed in the brain and is involved in the development and maintenance of neural stem cells. The protein is composed of two subunits, Hoxd-As1 and Hoxd-As2, which are capable of forming a binary complex with each other. Hoxd-As2 has been shown to play a critical role in the regulation of neural stem cell stemness and differentiate into functional neurons.

The Hoxd-As2 gene

The Hoxd-As2 gene is located on chromosome 6 and encodes a protein that is composed of 214 amino acid residues. The protein has a molecular weight of 29 kDa and a calculated pI of 5.6. Hoxd-As2 is predominantly expressed in the brain, and is also found in other tissues such as heart, lung, and liver.

The structure of Hoxd-As2

The Hoxd-As2 protein has a characteristic alpha-helical structure, with a distinct N-terminal and C-terminal region. The N-terminal region is rich in amino acids that are involved in the formation of the protein-protein interaction and in the regulation of stem cell biology. The C-terminal region is involved in the regulation of the protein's stability and localization to the plasma membrane.

Hoxd-As2's role in neural stem cells

Hoxd-As2 is a key regulator of neural stem cells (NSCs), which are a diverse set of cells that have the ability to self-renew and differentiate into a variety of cell types in the nervous system. NSCs are found in various tissues of the body, including the brain, and are responsible for the development and maintenance of the nervous system.

Hoxd-As2 plays a critical role in the regulation of NSCs by promoting their plasticity and promoting the formation of functional neurons. Hoxd-As2 has been shown to promote the expansion of NSCs through the production of Neurotrophins (NTs), which are cytokines that promote the growth, survival, and differentiation of NSCs.

Hoxd-As2 has also been shown to regulate the differentiation of NSCs into functional neurons. NSCs have been shown to differentiate into functional neurons that are capable of transmitting electrical signals in the brain. The ability of NSCs to differentiate into functional neurons is critical for the development and maintenance of the nervous system, and is a key factor in the development of neurological disorders.

Hoxd-As2's role in neurological disorders

Hoxd-As2 is involved in the development and maintenance of neural stem cells, which are a key factor in the development and treatment of neurological disorders. Many neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, are characterized by the loss of NSCs and the dysfunction of NSCs.

Hoxd-As2 has been shown to be involved in the development and progression of several neurological disorders. For example, Hoxd-As2 has been shown to be involved in the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. Hoxd-As2 has also been shown to be involved in the development of ischemic stroke, which is a common cause of death and disability in the brain.

Hoxd-As2 is also involved in the regulation of pain, and has been shown to be involved in the development and progression of chronic pain.

Hoxd-As2 as a drug target

Hoxd-As2 is a potential drug target for several neurological disorders. Hoxd-As2 has been shown to be involved in the development and progression of several neurological disorders, making it a promising target

Protein Name: HOXD Cluster Antisense RNA 2

The "HOXD-AS2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HOXD-AS2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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