HS3ST1: A Gene Involved in Cellular Signaling and DNA Replication

Target Name: HS3ST1

NCBI ID: G9957

HS3ST1

HS3ST1: A Gene Involved in Cellular Signaling and DNA Replication

HS3ST1, also known as HS3S1-HUMAN, is a gene that encodes a protein known as human short linear repeats (HSR) 3 (also known as HSP70), which is a family of proteins that are characterized by the presence of a short linear repeat. These proteins are known to play a variety of roles in cellular processes, including DNA repair, gene expression, and cellular signaling.

One of the unique features of HS3ST1 is its location in the human genome. It is located on chromosome 16, which is one of the chromosomes that makes up the X chromosome. This means that HS3ST1 is only expressed in females, as the X chromosome is only active in females. This is important for understanding the function of the protein, as it may have different effects in males.

The protein encoded by HS3ST1 is a 14-kDa protein that is expressed in a variety of tissues and cells in the body. It is primarily expressed in the brain, as well as in other organs and tissues. The protein is characterized by a number of unique features, including its ability to form inclusion-containing structures, such as alpha-helices, which are long, scroll-like structures that can form when two proteins are coiled together.

One of the key functions of HS3ST1 is its role in cellular signaling. It is involved in a variety of signaling pathways, including the regulation of cell growth, differentiation, and survival. It is also involved in the regulation of DNA replication and repair, which are important processes that are critical for the maintenance of cellular health.

Another important function of HS3ST1 is its role in gene expression. It is a key regulator of gene expression, and is involved in the regulation of a wide variety of gene products. It is also involved in the regulation of RNA stability and translation, which are important processes that are critical for the production of proteins from mRNA.

In addition to its role in cellular signaling and gene expression, HS3ST1 is also involved in the regulation of DNA replication and repair. It is a key regulator of the DNA damage response, which is a critical process that helps the cell respond to DNA damage and ensure the integrity of the genetic material. It is also involved in the regulation of DNA replication, which is a critical process that is necessary for the production of new copies of the genetic material.

Overall, HS3ST1 is a gene that is involved in a wide variety of cellular processes that are critical for the maintenance of cellular health. Its unique location in the human genome and its ability to form inclusion-containing structures make it an attractive target for research into the regulation of cellular processes. Further research is needed to fully understand the functions of HS3ST1 and its potential as a drug target or biomarker.

Protein Name: Heparan Sulfate-glucosamine 3-sulfotransferase 1

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:9346953, PubMed:8900198, PubMed:9988768). Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) (PubMed:8900198, PubMed:9988768). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site (PubMed:8900198, PubMed:9988768)

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•   general information;
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•   protein biological mechanisms;
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•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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