PGDIS: Key Enzyme Regulating Inflammation and Immune Function

Target Name: HPGDS

NCBI ID: G27306

HPGDS

PGDIS: Key Enzyme Regulating Inflammation and Immune Function

Prostaglandin-H2 D-isomerase (PGDIS) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a key enzyme in the synthesis of prostaglandins, which are a family of inflammatory compounds that play a crucial role in the regulation of various physiological processes in the body.

One of the unique aspects of PGDIS is its structure and function. It is a single-chain protein that consists of 154 amino acids. It has a catalytic active site at its N-terminus, which allows it to catalyze the conversion of pro-prostaglandins to their biologically active forms. PGDIS also has a distinct N-endopeptide that is located at its C-terminus.

PGDIS is involved in the regulation of a wide range of physiological processes that are critical to human health. One of its primary functions is the regulation of inflammation. Prostaglandins are involved in the recruitment of immune cells to sites of inflammation, as well as the regulation of their activation and function. PGDIS is also involved in the regulation of pain and inflammation.

Another important function of PGDIS is its role in the regulation of cell signaling. Prostaglandins can act as both signaling molecules and signaling intermediates. They can interact with various intracellular signaling systems, including the G-protein-coupled receptor (GPCR) system. PGDIS is also involved in the regulation of cell adhesion, as well as the regulation of cell signaling through the production of various signaling molecules, including chemokines and neurotransmitters.

PGDIS is also involved in the regulation of the immune response. Prostaglandins play a critical role in the regulation of immune cell function, including the regulation of T-cell proliferation and differentiation. PGDIS is also involved in the regulation of the production of antibodies, as well as the regulation of the complement system.

In addition to its involvement in the regulation of inflammation and immune function, PGDIS is also involved in the regulation of various physiological processes that are critical to human health. It is involved in the regulation of blood pressure, as well as the regulation of blood glucose levels. PGDIS is also involved in the regulation of cholesterol levels, as well as the regulation of hormone production.

PGDIS is also involved in the regulation of cell signaling and metabolism. Prostaglandins can interact with various intracellular signaling systems, including the PI3K/Akt signaling system, as well as the Src/FAK signaling system. PGDIS is also involved in the regulation of cell adhesion, as well as the regulation of cell signaling through the production of various signaling molecules, including chemokines and neurotransmitters.

In conclusion, PGDIS is a key enzyme that is involved in the regulation of various physiological processes that are critical to human health. Its function as a critical regulator of inflammation and immune function makes it an attractive target for drug development. Additionally, its role in the regulation of cell signaling and metabolism makes it a potential biomarker for various diseases. Further research is needed to fully understand the role of PGDIS in the regulation of human physiology and to develop effective treatments for various diseases.

Protein Name: Hematopoietic Prostaglandin D Synthase

Functions: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide

The "HPGDS Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HPGDS comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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