HPN: A Protein That Protects DNA From Damage (G3249)

Target Name: HPN

NCBI ID: G3249

Content of Review Report on HPN Target / Biomarker

HPN

HPN: A Protein That Protects DNA From Damage

HPN, or hepsin, is a protein that is expressed in various tissues throughout the body, including the liver, spleen, and kidneys. It is a type of nucleic acid-binding protein (NABP) that is known for its ability to bind to and protect DNA from damage caused by various environmental agents, such as viruses and chemicals.

The discovery and characterization of HPN has important implications for the study of DNA damage and repair, as well as the development of new therapeutic approaches. In recent years, researchers have been interested in investigating the potential of drugs that target HPN in order to treat a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the reasons for the interest in HPN is its unique ability to interact with DNA in a way that is distinct from other proteins that are known to bind to DNA. This interaction allows HPN to play a critical role in the immune system and the regulation of gene expression.

HPN is a member of the nucleic acid-binding protein (NABP) family, which includes a variety of proteins that are characterized by their ability to bind to specific nucleic acid sequences. This family of proteins is important for the regulation of DNA replication, transcription, and repair, as well as the regulation of cellular signaling pathways.

One of the key functions of HPN is its ability to interact with specific DNA sequences. This interaction is mediated by the protein's amino acid residues, which are able to form a stable complex with the nucleic acid. This interaction allows HPN to protect DNA from damage caused by environmental agents, such as viruses and chemicals.

In addition to its role in DNA protection, HPN is also involved in the regulation of gene expression. This is accomplished through the interaction between HPN and specific DNA-binding proteins, which are able to alter the levels of gene expression in response to various environmental cues.

The ability of HPN to interact with DNA and regulate gene expression makes it an attractive target for drug development. In addition to its potential as a therapeutic agent, HPN is also a potential biomarker for a variety of diseases. For example, the levels of HPN have been shown to be elevated in the brains of individuals with neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.

The characterization of HPN has also led to new insights into the mechanisms of DNA damage and repair. For example, researchers have found that HPN is involved in the repair of DNA damage caused by exposure to environmental agents, such as radiation and chemicals. This suggests that HPN may have a role in the regulation of DNA repair pathways, which are important for the maintenance of cellular health.

In conclusion, HPN is a protein that is expressed in various tissues throughout the body that is known for its ability to bind to and protect DNA from damage caused by various environmental agents. The discovery and characterization of HPN has important implications for the study of DNA damage and repair, as well as the development of new therapeutic approaches. Further research is needed to fully understand the role of HPN in these processes and to explore its potential as a therapeutic or biomarker.

Protein Name: Hepsin

Functions: Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890)

The "HPN Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HPN comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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