hST6Gal2: A Potential Drug Target and Biomarker (G84620)

Target Name: ST6GAL2

NCBI ID: G84620

ST6GAL2

hST6Gal2: A Potential Drug Target and Biomarker

Introduction

Human stem cells (hStemCs) are a source of great potential for the development of new therapeutic approaches to various diseases, including cancer. One of the challenges in the use of hStemCs for therapeutic applications is the difficulty in differentiating between hStemCs and other cell types, such as cancer cells. To address this challenge, researchers have been investigating the hST6Gal2 gene, which has been shown to be a potential drug target and biomarker in various diseases.

The hST6Gal2 gene

The hST6Gal2 gene is a member of the ST6 gene family, which encodes for the stem cell marker GFP (green fluorescent protein). The ST6 gene family is a subset of the POU5F1 gene family, which is characterized by the presence of a specific transcription factor Binding site (POU5F1-GFP) in the gene.

Cells expressing hST6Gal2

In vivo, the protein encoded by the hST6Gal2 gene is modified into a green fluorescent protein (GFP), which can be observed under a microscope. When the hST6Gal2 gene is activated, GFP can be observed through fluorescence microscopy, allowing scientists to detect whether hST6Gal2 gene expression is present in the cell.

Expression of hST6Gal2

The expression of hST6Gal2 gene can be regulated in various ways, including post-transcriptional modification, RNA-binding protein (RBP) binding and protein interaction. Among them, RBP binding is one of the most significant ways to regulate gene expression.

Studies have shown that the expression of hST6Gal2 gene can regulate biological processes such as cell cycle, proliferation and apoptosis by binding to RBP. In addition, the hST6Gal2 gene can also interact with a variety of proteins, including interactions with proteins such as CDK4, CDK6, p21 and p53. These interactions help regulate biological processes such as cell cycle, growth, and apoptosis.

Biological functions of hST6Gal2

The hST6Gal2 gene plays an important role in a variety of diseases. For example, in breast cancer, the expression level of hST6Gal2 gene is high and is related to the progression and invasion ability of breast cancer.

Knockdown of hST6Gal2 gene

hST6Gal2 gene knockdown can be achieved in a variety of ways, including gene editing technology, RNA interference, and protein inhibition. These technologies can effectively reduce the expression level of hST6Gal2 gene, thereby inhibiting the progression and invasion ability of breast cancer.

The therapeutic value of hST6Gal2 gene

As a drug target, the hST6Gal2 gene has important value in the treatment of breast cancer and other diseases. By inhibiting the expression of the hST6Gal2 gene, the progression and invasion ability of breast cancer can be inhibited, thereby improving the therapeutic effect.

Biological activity of hST6Gal2 gene

The hST6Gal2 gene plays an important role in a variety of diseases. For example, in breast cancer, the expression level of hST6Gal2 gene is high and is related to the progression and invasion ability of breast cancer. In addition, the hST6Gal2 gene can also interact with a variety of proteins, including interactions with proteins such as CDK4, CDK6, p21 and p53. These interactions help regulate biological processes such as cell cycle, growth, and apoptosis.

The therapeutic value of hST6Gal2 gene

As a drug target, the hST6Gal2 gene has important value in the treatment of breast cancer and other diseases. By inhibiting the expression of the hST6Gal2 gene, the progression and invasion ability of breast cancer can be inhibited, thereby improving the therapeutic effect.

Protein Name: ST6 Beta-galactoside Alpha-2,6-sialyltransferase 2

Functions: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids

The "ST6GAL2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ST6GAL2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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