PPP1R35: A Potential Drug Target and Biomarker for Protein Phosphatase 1 Regulatory Subunit 35

Target Name: PPP1R35

NCBI ID: G221908

PPP1R35

PPP1R35: A Potential Drug Target and Biomarker for Protein Phosphatase 1 Regulatory Subunit 35

Introduction

Protein phosphorylation is an important cell signal transduction pathway that plays a key role in regulating various physiological processes such as cell growth, proliferation, differentiation, and apoptosis. Among many phosphorylases, protein phosphatase 1 (PP1) is an important enzyme widely present in various organisms. PP1 has multiple functions in cells, such as substrate-specific recognition, phosphorylation modification, and substrate binding. As a unique structural domain, PP1 subunit 35 (PP1R35) has important biological functions in organisms. This article will introduce the structure, function and potential of PP1R35 as a drug target and biomarker.

Structure and function of PP1R35

PP1R35 is a 110-amino-acid protein whose structural domain includes a conserved 伪-helix, a short 尾-curl, a long 尾-伪-尾 sheet and a conserved tail. The active center of PP1R35 is a phosphorylation site located at the N-terminus of the polypeptide chain. This domain is highly specific, allowing it to recognize specific substrates such as acetyl-CoA.

PP1R35 plays an important role in a variety of biological processes. During cell proliferation and apoptosis, PP1R35 participates in a series of complex signal transduction pathways. In the cell cycle, PP1R35 plays a role in the G1 phase, S phase and G2 phase to regulate cell proliferation and growth. In addition, during the process of cell apoptosis, the role of PP1R35 is particularly obvious. Studies have shown that phosphorylation modification of PP1R35 plays a key role in apoptosis, such as increasing the rate of apoptosis and enhancing the sensitivity of apoptosis.

as a drug target

As a protein with multiple biological functions, PP1R35 is considered a potential drug target. At present, drug research on PP1R35 mainly focuses on the following aspects:

1. Inhibiting PP1R35 activity: Many studies have been devoted to finding compounds that can inhibit PP1R35 activity. These compounds can be synthesized using a variety of methods, such as synthetic inhibitors, domain-specific inhibitors, and substrate-specific inhibitors. These inhibitors can significantly reduce the phosphorylation activity of PP1R35, thereby inhibiting its biological activity.

2. Increase PP1R35 activity: In contrast to inhibiting PP1R35 activity, some studies focus on increasing the phosphorylation activity of PP1R35. These compounds usually have specific structural features and can carry out specific chemical modifications on the active center of PP1R35, thereby enhancing the phosphorylation activity of PP1R35.

as biomarkers

PP1R35 plays an important role in many biological processes and therefore has broad application prospects as a biomarker. Here are some possibilities for utilizing PP1R35 as a biomarker:

1. Cell cycle specificity: Due to the multiple functions of PP1R35 in the cell cycle, such as participating in mitosis, spindle formation, and cell cycle regulation, PP1R35 can be used as a cell cycle-specific biomarker. By detecting the phosphorylation level of PP1R35, cell cycle status can be accurately assessed.

2. Apoptosis specificity: As mentioned before, PP1R35 plays an important role in the apoptosis process. Therefore, the phosphorylation level of PP1R35 can be used as a specific biomarker for apoptosis. By detecting the phosphorylation level of PP1R35, the apoptotic status of cells can be accurately assessed.

3. Drug development: As a potential drug target, PP1R35 can use its phosphorylation activity as a target for drug development. By synthesizing PP1R35 phosphorylation inhibitors with specific structures, the phosphorylation activity of PP1R35 can be inhibited, thereby achieving the purpose of drug development.

in conclusion

As a protein with multiple biological functions, PP1R35 plays an important role in various physiological processes such as cell proliferation, apoptosis, and signal transduction. At the same time, as a unique structural domain, PP1R35 is also considered a potential drug target. By regulating its phosphorylation activity, the biological activity of PP1R35 can be specifically inhibited or improved, providing precise regulators for a variety of biological processes. Therefore, PP1R35 has broad application prospects as a biomarker and drug target.

Protein Name: Protein Phosphatase 1 Regulatory Subunit 35

Functions: During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with RTTN, leading to the centriole to centrosome conversion (PubMed:30168418, PubMed:30230954). In addition, may play a role in the primary cilia assembly (By similarity)

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