OASL: Research on oxidative stress-induced neurodegeneration (G8638)

Target Name: OASL

NCBI ID: G8638

OASL

OASL: Research on oxidative stress-induced neurodegeneration

OASL (Oxidative stress-induced neurodegeneration) is a neurodegenerative disease caused by the oxidative stress caused by an imbalance of reactive oxygen species (ROS) in the brain. OASL is characterized by the progressive loss of neurons and the disruption of neural circuits in the brain , leading to the symptoms of cognitive decline, including memory loss, decline in attention, and decreased overall quality of life.

The OASL mouse model is a well-established model for studying the effects of oxidative stress on the brain. In this model, mice are exposed to oxidative stress caused by the expression of superoxide yangming-generating enzyme (SOD-1) in response to an infection with the bacteria Pseudomonas aeruginosa. SOD-1 is a protein that generates reactive oxygen species (ROS) when it is exposed to oxygen, which can cause damage to cells and contribute to the development of oxidative stress.

In the OASL mouse model, the expression of SOD-1 is increased in the brain following exposure to Pseudomonas aeruginosa, leading to an imbalance of ROS that can cause damage to the brain. This damage is characterized by the progressive loss of neurons and the disruption of neural circuits, as well as an increase in the levels of neurotoxins in the brain.

The study of OASL has identified several potential drug targets that can be targeted to treat this disease. One potential target is the neurotransmitter serotonin, which is involved in the regulation of mood, appetite, and sleep. In individuals with OASL, the levels of serotonin in the brain are disrupted, which can contribute to the symptoms of the disease.

Another potential drug target is the antioxidant NAD+, which is involved in the regulation of cellular processes and is a key player in the antioxidant response to oxidative stress. In individuals with OASL, the levels of NAD+ in the brain are decreased, which can contribute to the exacerbation of the symptoms of the disease.

In addition to these potential targets, the study of OASL has also identified several potential biomarkers that can be used to diagnose and monitor the progress of the disease. These biomarkers include the level of SOD-1 in the brain, the levels of neurotoxins in the brain, and the levels of NAD+ in the brain.

Overall, OASL is a neurodegenerative disease caused by the oxidative stress caused by an imbalance of ROS in the brain. The OASL mouse model is a well-established model for studying the effects of oxidative stress on the brain, and the study of OASL has identified Several potential drug targets and biomarkers that can be used to treat this disease. Further research is needed to develop effective therapies for OASL and to improve the quality of life for individuals with this disease.

Protein Name: 2'-5'-oligoadenylate Synthetase Like

Functions: Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L

The "OASL Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OASL comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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