OBP2A: A Protein Regulating Protein Stability and Localization in The ER

Target Name: OBP2A

NCBI ID: G29991

OBP2A

OBP2A: A Protein Regulating Protein Stability and Localization in The ER

Obp2a, also known as OBP2A variant alpha, is a protein that is expressed in the endoplasmic reticulum (ER) and is involved in the regulation of protein stability and localization in the cell. It is a 21-kDa protein that consists of two distinct N -terminus regions, a transmembrane region (TMR), and an intracellular tail region (ITR).

OBP2A is a key regulator of protein stability and localization in the ER, and is involved in the delivery of proteins to the cytosol for subsequent degradation or processing. It does this by playing a critical role in the formation of the endoplasmic reticulum-protein interaction complex (ERPIC), a protein-protein interaction that is essential for protein delivery to the ER.

The N-terminus region of OBP2A contains a domain that is similar to known transmembrane protein (TMP) domains, which are involved in protein-protein interactions and localization to the ER. This domain is responsible for the interaction between OBP2A and the transmembrane protein protein protein tyrosine kinase (TK)2. This interaction between OBP2A and TK2 is critical for the formation of the ERPIC and for the delivery of OBP2A-containing proteins to the ER.

The C-terminus region of OBP2A contains a domain that is similar to known cytoplasmic protein (CP) domains, which are involved in protein localization to the cytosol. This domain is responsible for the interaction between OBP2A and the cytosolic protein protein quality control (PQC ) complex, which is responsible for the quality control of proteins before they are delivered to the cytosol for degradation or processing.

OBP2A is also involved in the regulation of protein stability in the ER. It does this by playing a critical role in the formation of the ER-associated degradation (ERAD) complex, a protein-protein interaction that is essential for the degradation of proteins in the ER.

In addition to its role in protein stability and localization in the ER, OBP2A is also involved in the regulation of protein synthesis and translation in the cell. It does this by playing a critical role in the regulation of the cytosolic protein translation machinery (CTM) , which is responsible for the translation of mRNAs from the cytoplasmic ribosome (CBRNA) to the endoplasmic ribosome (ERRS).

OBP2A is a protein that is expressed in the ER and is involved in the regulation of protein stability and localization in the cell. Its N-terminus region contains a TMP domain that is responsible for the interaction with the transmembrane protein protein tyrosine kinase (TK2 ), while its C-terminus region contains a PQC domain that is responsible for the interaction with the cytosolic protein protein quality control (PQC) complex. In addition to its role in protein stability and localization in the ER, OBP2A is also involved in the regulation of protein synthesis and translation in the cell.

OBP2A is a drug target (or biomarker) that may be targeted by small molecules or antibodies to inhibit its function. This could be useful for the development of new treatments for various diseases, such as cancer, neurodegenerative diseases, and autoimmune disorders.

Overall, OBP2A is a protein that is involved in the regulation of protein stability and localization in the ER and is a potential drug target (or biomarker) that may be targeted by small molecules or antibodies to inhibit its function. Further research is needed to fully Understand the role of OBP2A in the regulation of protein stability and localization in the ER and to develop new treatments based on its function as a drug target.

Protein Name: Odorant Binding Protein 2A

Functions: Binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids, including undecanal, palmitic acid, efficient aldehydes, benzenic aldehydes, heterocyclic aldehydes and aliphatic acids

The "OBP2A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OBP2A comprehensively, including but not limited to:
•   general information;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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