Target Name: ONECUT3
NCBI ID: G390874
Review Report on ONECUT3 Target / Biomarker Content of Review Report on ONECUT3 Target / Biomarker
ONECUT3
Other Name(s): one cut homeobox 3 | One cut domain, family member 3 | OC3 | One cut homeobox 3 | OC-3 | ONEC3_HUMAN | transcription factor ONECUT-3 | Transcription factor ONECUT-3 | One cut domain family member 3

Unlocking the Potential of ONECUT3: A drug Target and Biomarker

Introduction

Oncogene-associated gene splicing plays a crucial role in tumorigenesis and progression. The expression of splicable genes is up-regulated in tumor cells, leading to inaccuracy of genetic information and disorder of cell function. Therefore, studying the role of ONECUT3 in tumor occurrence and development has important biological significance.

ONECUT3 Overview

ONECUT3 (One-Cut Homeobox 3) is a conserved gene widely expressed in multiple species. In mammals, the protein encoded by the ONECUT3 gene is named bone and cartilage tissue-specific stromal cell factor (Mesenchymal stem cell factor, MSCF). MSCF plays a key role in the differentiation and regeneration of osteogenesis and cartilage tissue, and the MSCF signaling pathway has broad application prospects in the fields of fracture repair, tissue engineering, and regenerative medicine.

Pharmacological significance of ONECUT3

1. Inhibit ONECUT3 activity: ONECUT3 expression is up-regulated in tumor cells. By inhibiting ONECUT3 activity, the growth and spread of tumor cells can be inhibited.

2. Anti-tumor activity: Inhibition of ONECUT3 can lead to apoptosis of tumor cells and inhibit the proliferation of tumor cells.

3. Regulate MSCF signaling pathway: ONECUT3 can bind to MSCF receptors, thereby regulating the MSCF signaling pathway. This provides new ideas for studying the role of MSCF in tumor treatment.

4. Potential drug target: ONECUT3 is a pharmacological target that can be used as a potential anti-tumor drug by inhibiting ONECUT3 activity.

biomedical research

1. ONECUT3 expression and tumorigenesis: In order to study the role of ONECUT3 in tumorigenesis, researchers conducted quantitative studies on ONECUT3 expression in a variety of tumor cell lines. The results indicate that upregulation of ONECUT3 expression is a key factor in tumorigenesis.

2. ONECUT3 and MSCF: Studies have shown that ONECUT3 can bind to MSCF receptors, thereby regulating the MSCF signaling pathway. This provides new ideas for studying the role of MSCF in tumor treatment.

3. The inhibitory effect of ONECUT3: Researchers have studied the inhibitory effect of ONECUT3 on a variety of tumor animal models. The results show that ONECUT3 inhibition can significantly inhibit the growth and spread of tumor cells.

4. Pharmacological significance of ONECUT3: Based on the inhibitory effect of ONECUT3, researchers are exploring ONECUT3 as a potential anti-tumor drug.

Clinical application prospects

1. Bone and cartilage tissue diseases: ONECUT3 plays an important role in bone and cartilage tissue. Inhibiting ONECUT3 activity can treat fractures, osteoarthritis and other bone and cartilage diseases.

2. Tissue engineering and regenerative medicine: ONECUT3 can promote the regeneration of osteogenic and cartilage tissues, providing new methods for tissue engineering and regenerative medicine.

3. Drug research and development: ONECUT3 is a pharmacological target and can be used as a research object for anti-tumor drugs in the future.

Conclusion

As a conserved gene widely expressed in multiple species, ONECUT3 plays an important role in tumor occurrence and development. Inhibiting ONECUT3 activity can inhibit the growth and spread of tumor cells and has anti-tumor activity. At the same time, ONECUT3 can bind to MSCF receptors and regulate the MSCF signaling pathway, providing new ideas for studying the role of MSCF in tumor treatment. Based on the inhibitory effect of ONECUT3, researchers are exploring ONECUT3 as a potential anti-tumor drug, bringing new hope for tumor treatment.

Protein Name: One Cut Homeobox 3

Functions: Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity)

The "ONECUT3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ONECUT3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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