ODC1: A Protein Regulating DNA Damage Response in Cancer (G4953)

Target Name: ODC1

NCBI ID: G4953

ODC1

ODC1: A Protein Regulating DNA Damage Response in Cancer

ODC1 (Oxidative DNA Damage-Inducible) is a protein that plays a crucial role in DNA repair and has been identified as a potential drug target in the field of cancer. The discovery of ODC1 and its functions have important implications for the development of new cancer therapies.

ODC1 was first identified as a protein that is expressed in various tissues and is involved in the repair of DNA damage. The damage to DNA can be caused by various factors such as radiation, chemicals, or errors in DNA replication. ODC1 helps to repair the damage by induce the DNA repair pathway.

ODC1 functions as a transcription factor that regulates the expression of genes involved in the DNA repair pathway. It plays a key role in the regulation of the DNA damage response (DDR), which is a set of cellular pathways that respond to DNA damage and ensure the integrity of the genetic material.

The DDR is a complex process that involves various cellular pathways, including the Nucleotide-Capped Enzyme (NCE) complex, which is responsible for repairing DNA damage. ODC1 is a key regulator of this pathway, and its function in the DDR has been well- studied.

Studies have shown that ODC1 plays a crucial role in the regulation of the NCE complex. The NCE complex is a complex of proteins that work together to repair DNA damage. ODC1 has been shown to interact with the NCE complex and regulate its function.

In addition to its role in the NCE complex, ODC1 has also been shown to play a key role in the regulation of the DNA damage response pathway. ODC1 has been shown to regulate the accumulation of DNA damage at the site of an original DNA double strand. break. This accumulation of DNA damage is a hallmark of a DNA double strand break and is a key factor in the development of cancer.

The accumulation of DNA damage at the site of a double strand break can lead to the formation of a cell cycle arrest complex, which can lead to the inhibition of cell growth and the formation of a tumor suppressor state. ODC1 has been shown to regulate the formation of this cell cycle arrest complex, which has implications for the development of cancer.

In conclusion, ODC1 is a protein that plays a crucial role in the regulation of the DNA damage response pathway. Its function in this pathway has important implications for the development of cancer therapies. Further research is needed to fully understand the role of ODC1 in the DDR and its potential as a drug target.

Protein Name: Ornithine Decarboxylase 1

Functions: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis

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