Target Name: OPHN1
NCBI ID: G4983
Review Report on OPHN1 Target / Biomarker Content of Review Report on OPHN1 Target / Biomarker
OPHN1
Other Name(s): OPHN1_HUMAN | ARHGAP41 | MRXSBL | mental retardation, X-linked 60 | MRX60 | oligophrenin 1 | Oligophrenin-1 | oligophrenin-1, Rho-GTPase activating protein | Rho-GTPase activating protein | Oligophrenin 1 | OPN1

OPHN1 Regulates Electron Transport Chain in Eukaryotic Cells

OPHN1 (Oxidative Phosphorylation Nuclear protein 1) is a protein that plays a crucial role in the process of oxidative phosphorylation (OXPHOS) in eukaryotic cells. OXPHOS is the final step in the electron transport chain that generates ATP fromADenosine (Adenosine) and Pyruvate (Py ) via a series of complex chemical reactions. OPHN1 is a key protein that helps to regulate this process by ensuring that it runs smoothly and efficiently.

The OPHN1 protein is composed of 1,202 amino acids and has a calculated molecular mass of 17.5 kDa. It is a single-chain protein that is expressed in most eukaryotic cells and is primarily localized to the mitochondria. OPHN1 is a cytoplasmic protein, which means that it is primarily located within the cytoplasm of the cell rather than the cell nucleus.

One of the key functions of OPHN1 is to regulate the activity of the electron transport chain. The electron transport chain is a complex series of chemical reactions that involve the transfer of electrons from the electron donor to the electron acceptor. This process is essential for the production of ATP in the cell. OPHN1 helps to regulate the activity of the electron transport chain by ensuring that the chain runs smoothly and efficiently.

PHN1 is involved in the regulation of the electron transport chain by participating in the assembly and disassembly of the chain. It does this by playing a key role in the formation of the outer mitochondrial membrane, which is responsible for the regulation of the flow of electrons into and out of the mitochondria. OPHN1 helps to assemble the outer mitochondrial membrane by interacting with the protein p21 and the protein Osmosis-associated protein (OAP) 1.

PHN1 is also involved in the regulation of the electron transport chain by interacting with the protein

Protein Name: Oligophrenin 1

Functions: Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity)

The "OPHN1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OPHN1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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