OAZ3: A Protein Involved in Cell Signaling, Inflammation and Stress Response

Target Name: OAZ3

NCBI ID: G51686

OAZ3

OAZ3: A Protein Involved in Cell Signaling, Inflammation and Stress Response

OAZ3 (Oxidized and Activated Zinc finger protein-3) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a zinc finger protein, which means that it contains a zinc atom that is part of a finger-like structure. OAZ3 is involved in a variety of physiological processes in the body, including cell signaling, inflammation, and stress response.

One of the unique features of OAZ3 is its ability to be modified by other proteins. This is known as post-translational modification (PTM), which involves the addition or removal of functional groups to a protein after its synthesis. OAZ3 can be modified by various enzymes, including casein kinase (CK), which is a protein that is involved in cell signaling.

CK is a ubiquitous enzyme that is involved in many different cellular processes. It is a non-linear protein that consists of a catalytic active site and a variable region. The variable region of CK contains a region that can be modified by various PTMs, including OAZ3.

Azathioprine is an immunosuppressant drug that is used to treat a variety of autoimmune and inflammatory disorders. It works by inhibiting the activity of the immune system, which can help to reduce inflammation and improve the symptoms of these disorders.

Azathioprine is also known as 2-mercaptoethanesulfonic acid (2-MES), which is a derivative of the amino acid cysteine. 2-MES is a potent inhibitor of the enzyme casein kinase (CK), which is involved in many cellular processes, including cell signaling, DNA replication, and stress response.

In addition to its role in cell signaling, CK is also involved in the regulation of inflammation. It is a potent inhibitor of the enzyme nuclear factor kappa B (NF-kappa-B), which is involved in the production of inflammatory cytokines. By inhibiting NF-kappa-B, CK can help to reduce inflammation and improve the symptoms of inflammatory disorders.

OAZ3 is also involved in the regulation of stress response. It is a potent activator of the protein heat shock protein (HSP70), which is involved in the regulation of stress response. HSP70 is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is involved in the regulation of stress response, including the expression of genes involved in stress response, such as stress-responsive genes.

In conclusion, OAZ3 is a protein that is involved in a variety of physiological processes in the body. It is a zinc finger protein that can be modified by various enzymes, including casein kinase (CK). CK is a ubiquitous enzyme that is involved in many different cellular processes, including cell signaling, DNA replication, and stress response. OAZ3 is also involved in the regulation of cell signaling, inflammation, and stress response. As a potential drug target, OAZ3 may be useful in the treatment of a variety of autoimmune and inflammatory disorders.

Protein Name: Ornithine Decarboxylase Antizyme 3

Functions: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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