Target Name: OPN3
NCBI ID: G23596
Review Report on OPN3 Target / Biomarker Content of Review Report on OPN3 Target / Biomarker
OPN3
Other Name(s): OPN3 variant 1 | Encephalopsin | Opsin 3, transcript variant 1 | opsin 3 (encephalopsin, panopsin) | Panopsin | PPP1R116 | OPN3_HUMAN | protein phosphatase 1, regulatory subunit 116 | opsin 3 | Opsin-3 (isoform 1) | Opsin-3 | encephalopsin | ECPN

OPN3: A Potential Drug Target for Neurological Disorders

OPN3, also known as OPN3 variant 1, is a protein that is expressed in the nervous system and has been identified as a potential drug target for the treatment of various neurological disorders. OPN3 is a transmembrane protein that is characterized by its unique structure, which consists of a long extracellular domain, a short intracellular domain, and a unique N-terminus.

The OPN3 protein is involved in a variety of physiological processes in the nervous system, including the regulation of ion channels and the transmission of signals between neurons. OPN3 has been shown to play a role in the development and progression of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy.

One of the key challenges in studying OPN3 is its high degree of homogeneity, which can make it difficult to identify and target specific regions of the protein that are involved in its function. However, recent studies have identified several potential drug targets for OPN3, including the interaction with the protein known as TrkB, which is a key regulator of neurotransmitter release.

In addition to its role in the nervous system, OPN3 has also been shown to be involved in other biological processes, including cell signaling and inflammation. This suggests that OPN3 may have a broader impact on cellular biology and may be a valuable target for researchers interested in understanding the mechanisms underlying various neurological disorders.

OPN3 has also been shown to interact with several other proteins, including the protein known as CSF2, which is involved in the production of cerebrospinal fluid. This interaction suggests that OPN3 may be involved in the regulation of cerebrospinal fluid production and may be a potential target for treatments of various neurological disorders.

In conclusion, OPN3 is a protein that has been identified as a potential drug target for the treatment of various neurological disorders. Its unique structure and involvement in a variety of physiological processes make it a promising target for researchers interested in understanding the mechanisms underlying these disorders. Further studies are needed to determine the full extent of OPN3's role in the nervous system and to identify the most effective way to target its function.

Protein Name: Opsin 3

Functions: G-protein coupled receptor which selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin (PubMed:28842328, PubMed:31380578, PubMed:31097585). Binds both 11-cis retinal and all-trans retinal (PubMed:31097585). Regulates melanogenesis in melanocytes via inhibition of alpha-MSH-induced MC1R-mediated cAMP signaling, modulation of calcium flux, regulation of CAMK2 phosphorylation, and subsequently phosphorylation of CREB, p38, ERK and MITF in response to blue light (PubMed:28842328, PubMed:31097585). Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling (PubMed:31730232). Additionally regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade (PubMed:31730232). Required for TYR and DCT blue light-induced complex formation in melanocytes (PubMed:28842328). Involved in keratinocyte differentiation in response to blue-light (PubMed:30168605). Required for the UVA-mediated induction of calcium and mitogen-activated protein kinase signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts (PubMed:31380578). Plays a role in light-mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (By similarity). May be involved in photorelaxation of airway smooth muscle cells, via blue-light dependent GPCR signaling pathways (By similarity)

The "OPN3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OPN3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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