OGFOD3: A Protein Linked To Disease and Drug Development (G79701)
OGFOD3: A Protein Linked To Disease and Drug Development
OGFOD3, also known as 2-oxoglutarate and iron dependent oxygenase domain containing 3, is a protein that plays a crucial role in the antioxidant response of cells in the body. It is a key enzyme in the network of oxygen-carrying molecules called the antioxidant system, which is responsible for protecting the cell from damage caused by reactive oxygen species (ROS). Mutations in the OGFOD3 gene have been linked to a range of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, OGFOD3 has emerged as a promising drug target and a biomarker for a variety of diseases.
OGFOD3 is a protein that is expressed in a wide range of tissues throughout the body, including the brain, heart, liver, and muscle. It is a member of the superfamily of enzymes known as the oxygen-carrying domains (OCD), which includes a group of enzymes that are involved in the transfer of oxygen from the lungs to the tissues. The OCD enzymes are a subset of the NAD+-dependent enzymes, which are a group of enzymes that are involved in a variety of cellular processes, including energy metabolism and stress response.
One of the key functions of OGFOD3 is its role in the antioxidant response. ROS are highly reactive molecules that can cause damage to cells if they accumulate too much. OGFOD3 is involved in the transfer of oxygen from the lungs to the tissues, which allows it to help remove ROS from the body. This is important for maintaining the health and integrity of cells, as ROS can cause damage and contribute to a range of diseases.
Mutations in the OGFOD3 gene have been linked to a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that mutations in the OGFOD3 gene are associated with an increased risk of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Additionally, OGFOD3 mutations have been linked to an increased risk of cancer, particularly breast and ovarian cancer.
As a result, OGFOD3 has emerged as a promising drug target and a biomarker for a variety of diseases. Researchers are interested in using OGFOD3 as a target for drugs that can prevent or treat a range of conditions, including cancer, neurodegenerative diseases, and autoimmune disorders. This is because OGFOD3 is thought to be involved in the development and progression of many of these diseases, and targeting it may be a way to develop more effective therapies.
One approach that researchers are taking to target OGFOD3 is to use small molecules to interfere with its function. This is done by identifying molecules that can bind to specific regions of OGFOD3 and prevent it from carrying out its antioxidant functions. Researchers are also using techniques such as RNA interference and CRISPR/Cas9 to modify the expression of OGFOD3 and to study its role in different diseases.
Another approach that researchers are taking to target OGFOD3 is to use antibodies to block its function. This is done by creating antibodies that recognize specific regions of OGFOD3 and bind to them. Researchers are then able to use these antibodies to prevent OGFOD3 from carrying out its antioxidant functions, which can be useful for studying its role in different diseases.
In addition to its potential as a drug target, OGFOD3 is also being studied as a biomarker for a variety of diseases. This is done by using OGFOD3 as a protein that is expressed in a wide range of tissues and can be used as a marker for the presence of specific diseases. For example, OGFOD3 is being used to study the effects of a drug on cancer cells, and to assess the effectiveness of different treatments for neurodegenerative diseases.
Overall, OGFOD3 is a protein that plays a crucial role in the antioxidant response of cells in the body. Its mutations have been linked to a range of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, OGFOD3 has emerged as a promising drug target and a biomarker for a variety of diseases. Further research is needed to fully understand its role in the body and to develop effective therapies.
Protein Name: 2-oxoglutarate And Iron Dependent Oxygenase Domain Containing 3
The "OGFOD3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OGFOD3 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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