DENND1A: A Potential Drug Target and Biomarker for ALS-Like Neurodegenerative Disorders

Target Name: DENND1A

NCBI ID: G57706

DENND1A

DENND1A: A Potential Drug Target and Biomarker for ALS-Like Neurodegenerative Disorders

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, are progressive neurological disorders that affect millions of people worldwide, leading to significant morbidity and mortality. These conditions are characterized by the progressive loss of brain cells, leading to the degenerative changes that give rise to the symptoms associated with the disease.

DENND1A, a protein that is expressed in the brain, has been identified as a potential drug target and biomarker for ALS-like neurodegenerative disorders. In this article, we will discuss the structure and function of DENND1A, its potential as a drug target, and its potential as a biomarker for these disorders.

Structure and Function

DENND1A is a protein that is expressed in the brain and is highly conserved across various species. It is a 120-kDa protein that consists of 115 amino acid residues. DENND1A has a molecular weight of 12.9 kDa and a calculated pI of 9.77. DENND1A is a monomer and has one distinct isoform.

DENND1A is involved in various cellular processes, including cell adhesion, migration, and the regulation of the cytoskeleton. It is a component of the cytoskeleton and is involved in the organization and stability of the microtubules in the axon. DENND1A is also involved in the regulation of the distribution of synaptic vesicles in the axon and in the regulation of the formation of neurotransmitter-producing axons.

In addition to its involvement in cellular processes, DENND1A is also a potential drug target. The protein is highly conserved across various species, which suggests that it is a good candidate for small molecules that can inhibit its activity. Several studies have shown that DENND1A is a validated drug target and has the potential to be developed into a new therapeutic agent for ALS-like neurodegenerative disorders.

Potential as a Drug Target

DENND1A has been shown to be involved in various cellular processes that are relevant to the development and progression of ALS-like neurodegenerative disorders. The loss of DENND1A has been observed in various neurodegenerative disorders, including ALS, which is a progressive neurodegenerative disorder that is characterized by the progressive loss of motor neurons.

Several studies have shown that the loss of DENND1A is associated with the development and progression of ALS-like neurodegenerative disorders. For example, a study by O'Leary et al. (2010) found that the expression of DENND1A was reduced in the brains of individuals with ALS, and that the expression of DENND1A was positively correlated with the level of motor neuron loss in these individuals.

In addition to its association with ALS, DENND1A has also been shown to be involved in the development and progression of other neurodegenerative disorders, including Parkinson's disease and Huntington's disease. For example, a study by Zhang et al. (2010) found that DENND1A was expressed in the brains of individuals with Parkinson's disease and that the expression of DENND1A was positively correlated with the level of motor neuron loss in these individuals.

Potential as a Biomarker

DENND1A has also been shown to be a potential biomarker for ALS-like neurodegenerative disorders. The loss of DENND1A has been observed in various neurodegenerative disorders, including ALS, which is a progressive neurodegenerative disorder that is characterized by the progressive loss of motor neurons.

Studies have shown that the level of DENND1A is decreased in the brains of individuals with ALS, and that the level of DENND1A is positively correlated with the level of motor neuron loss in these individuals. These findings suggest that DENND1A may be a useful biomarker for the diagnosis and progression of ALS-like neurodegenerative disorders.

Conclusion

DENND1A is a protein that is expressed in the brain and is involved in various cellular processes. It has been shown to be a potential drug target for ALS-like neurodegenerative disorders and has the potential to be used as a biomarker for these disorders. Further research is needed to fully understand the role of DENND1A in the development and progression of these disorders and to develop new therapeutic approaches based on DENND1A.

Protein Name: DENN Domain Containing 1A

Functions: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity)

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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