Exploring the Potential Applications of DENND10 as a Drug Target or Biomarker

Target Name: DENND10

NCBI ID: G404636

DENND10

Exploring the Potential Applications of DENND10 as a Drug Target or Biomarker

Introduction

DENND10, a ten-member peptide derived from the nontranslated region of human exonuclease DENN (DNA endonuclease DNA-binding protein), has been identified as a promising drug target and biomarker for various diseases. Its unique structure, derived from a specific type of DNA -binding protein, has led to a high affinity for DNA-binding small molecules, making it an attractive candidate for drug development. In this article, we will explore the potential applications of DENND10 as a drug target or biomarker.

DENN Domain and its Functions

The DENN domain is a type of nucleotide-binding protein that contains a unique feature called a \"尾-sheet,\" which is a three-dimensional structure composed of a repeating array of beta-helices. The 尾-sheet in DENN domains is responsible for the protein's stability and stability-dependent interactions with DNA. DENN domains are found in various proteins, including nontranslated regions of nucleic acidases, DNA-binding proteins, and RNA-binding proteins.

One of the key features of DENN domains is their ability to bind specifically to DNA in a specific sequence. This is achieved through a combination of the 尾-sheet's three-dimensional structure, which allows for a more stable binding, and the presence of various electrostatic and hydrophobic interactions, which further enhance the protein's affinity for DNA.

Expression and Localization of DENN Domains

DENN domains are highly conserved across various species, which indicates that they have important functions in various cellular processes. One of the well-documented functions of DENN domains is their role in DNA-binding proteins. Many DNA-binding proteins, including transcription factors, have been shown to contain DENN domains. These domains play a crucial role in regulating DNA replication, transcription, and repair.

In addition to their functions in proteins, DENN domains have also been found to be expressed in various cell types, including cancer cells, where they may contribute to the development and progression of cancer. This suggests that DENN domains may be useful as drug targets or biomarkers for cancer therapies.

Potential Applications of DENN Domains as Drug Targets

DENN domains have been shown to be highly effective in drug development due to their unique properties, including stability, affinity for small molecules, and ability to interact with various drug molecules. Several studies have demonstrated the potential of using DENN domains as drug targets for various diseases, including cancer.

One of the most promising applications of DENN domains as drug targets is their ability to interact with small molecules that are known to be sensitive to protein-ligand interactions. Many small molecules, including drugs used to treat cancer, have been shown to interact with DENN domains. For example, the peptide API-1100 is a small molecule that has been shown to interact with the DENN domain of the protein HDT1, leading to the inhibition of its DNA-binding activity.

Another potential application of DENN domains as drug targets is their ability to interact with other proteins that are involved in disease progression. For instance, DENN domains have been shown to interact with the protein KRAS, which is involved in cancer cell growth and survival. Therefore , targeting DENN domains may be a promising strategy for cancer therapies.

Potential Applications of DENN Domains as Biomarkers

DENN domains have also been shown to be potential biomarkers for various diseases. Their unique properties, including stability, affinity for small molecules, and ability to interact with proteins, make them attractive candidates for diagnostic tools.

One of the most promising applications of DENN domains as biomarkers is their ability to detect changes in gene expression associated with diseases. For example, DENN domains have been shown to be expressed in various diseases, including cancer. Therefore, the analysis of DENN domain expression levels in tissues or fluids, such as blood or urine samples, may be a promising strategy for the diagnosis

Protein Name: DENN Domain Containing 10

Functions: Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP-bound form

The "DENND10 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DENND10 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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