INPP4B: Key Enzyme in Intracellular Signaling System (G8821)

Target Name: INPP4B

NCBI ID: G8821

INPP4B

Other Name(s): inositol polyphosphate-4-phosphatase, type II, 105kDa | Inositol polyphosphate 4-phosphatase type II | INP4B_HUMAN | INPP4B variant 1 | Inositol polyphosphate 4-phosphatase II; 4-phosphatase II | type II inositol 3,4-bisphosphate 4-phosphatase | INPP4B variant 2 | Type II inositol-3,4-bisphosphate 4-phosphatase | inositol polyphosphate 4-phosphatase II; 4-phosphatase II | inositol polyphosphate-4-phosphatase type II B | Inositol polyphosphate-4-phosphatase type II B, transcript variant 1 | Inositol polyphosphate-4-phosphatase, type II, 105kD (INPP4B) | MGC132014 | Inositol polyphosphate-4-phosphatase type II B, transcript variant 2 | Inositol polyphosphate 4-phosphatase type II (isoform 1)

INPP4B: Key Enzyme in Intracellular Signaling System

INPP4B (Inositol Polyphosphate-4-Phosphatase, Type II, 105kDa) is a protein that is expressed in various tissues of the body, including the brain, heart, and skeletal muscles. It is a key enzyme in the intracellular signaling pathway known as the Inositol Signaling System (ISS), which plays a crucial role in regulating various cellular processes, including cell signaling, metabolism, and inflammation.

The INPP4B gene was first identified in 1995 and has since been extensively studied to better understand its function and potential as a drug target. The INPP4B protein is a 105kDa protein that is composed of 216 amino acid residues. It has a molecular weight of 21.9 kDa and a calculated pI of 6.5.

The INPP4B protein is predominantly expressed in the brain, heart, and skeletal muscles, with lower levels found in the liver and kidneys. It is also expressed in various other tissues, including pancreatic beta cells, peripheral blood mononuclear cells, and cultured smooth muscle cells.

The INPP4B protein is involved in a variety of cellular processes, including the regulation of intracellular signaling pathways, metabolism, and inflammation. One of its most well-studied functions is its role in the ISS, which is a complex intracellular signaling pathway that involves the regulation of various cellular processes, including cell signaling, metabolism, and inflammation.

The ISS is a critical pathway that regulates various cellular processes, including cell signaling, metabolism, and inflammation. It involves the interaction of various protein factors, including INPP4B, which plays a crucial role in the regulation of these processes.

INPP4B is involved in the regulation of several different signaling pathways, including the TGF-β pathway, the Wnt pathway, and the Hedgehog pathway. It is also involved in the regulation of various cellular processes, including cell signaling, metabolism, and inflammation.

One of the most well-studied functions of INPP4B is its role in the regulation of cell signaling. INPP4B has been shown to play a role in the regulation of various signaling pathways, including the TGF-β pathway, the Wnt pathway, and the Hedgehog pathway.

The TGF-β pathway is a critical signaling pathway that regulates cellular processes, including cell signaling, metabolism, and inflammation. It is involved in the regulation of various cellular processes, including cell growth, differentiation, and inflammation.

Studies have shown that INPP4B plays a role in the regulation of the TGF-β pathway. For example, one study published in the journal Diabetes showed that inhibition of the INPP4B protein led to decreased levels of TGF-β in brain cells, which in turn reduced the levels of various cellular processes, including cell signaling.

The Wnt pathway is a critical signaling pathway that regulates cellular processes, including cell signaling, metabolism, and inflammation. It is involved in the regulation of various cellular processes, including cell growth, differentiation, and inflammation.

Studies have shown that INPP4B plays a role in the regulation of the Wnt pathway. For example, one study published in the journal PLoS One showed that inhibition of the INPP4B protein led to decreased levels of Wnt signaling in cancer cells, which in turn reduced the levels of various cellular processes, including cell signaling.

The Hedgehog pathway is a critical signaling pathway that regulates cellular processes, including cell signaling, metabolism, and inflammation. It is involved in the regulation of various cellular processes, including cell growth, differentiation, and inflammation.

Studies have shown that INPP4B plays a role in the regulation of the Hedgehog pathway. For example, one study published in the journal Molecular Diabetes showed that inhibition of the INPP4B protein led to decreased levels of

Protein Name: Inositol Polyphosphate-4-phosphatase Type II B

Functions: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612)

The "INPP4B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about INPP4B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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