PI Signaling: A Crucial Role in Cell Signaling and Survival (G200576)

Target Name: PIKFYVE

NCBI ID: G200576

PIKFYVE

PI Signaling: A Crucial Role in Cell Signaling and Survival

Phosphatidylinositol (PI) is a crucial signaling molecule in various cellular processes that play a vital role in cell signaling, including the regulation of cell growth, differentiation, and survival. The PI system is a highly conserved family of enzymes that catalyze the phosphorylation of PI and generate inositol triphosphate (IP3) as a side product. One of the best-studied PI enzymes is PIKFYVE (phosphatidylinositol 3-phosphate 5-kinase type III), which is involved in the regulation of various cellular processes, including cell signaling, DNA replication, and cell survival.

The PI system is a complex network of enzymes, including PIKFYVE, which consists of two subunits: a catalytic subunit and an regulatory subunit. The catalytic subunit consists of a catalytic center and a catalytic loop, while the regulatory subunit consists of a N-terminal region and a C-terminal region. The catalytic subunit catalyzes the phosphorylation of PI and generates IP3, while the regulatory subunit regulates the activity of the catalytic subunit.

PI signaling is a critical pathway in various cellular processes, including cell growth, differentiation, and survival. PI signaling is activated by the recruitment of several regulatory proteins, including GDP-bound regulatory proteins, which promote the formation of IP3 and the subsequent activation of downstream signaling pathways. The PI signaling pathway is also influenced by various intracellular signaling pathways, including the PI3K/Akt signaling pathway, which is involved in the regulation of cell growth, differentiation, and survival.

PI signaling is activated by the recruitment of several regulatory proteins, including GDP-bound regulatory proteins, which promote the formation of IP3 and the subsequent activation of downstream signaling pathways. The PI signaling pathway is also influenced by various intracellular signaling pathways, including the PI3K/Akt signaling pathway, which is involved in the regulation of cell growth, differentiation, and survival.

PI signaling is regulated by several intracellular signaling pathways, including the PI3K/Akt signaling pathway, which is involved in the regulation of cell growth, differentiation, and survival. The PI3K/Akt signaling pathway is activated by the recruitment of several regulatory proteins, including the PI3K protein, which is a key regulator of PI signaling, and the Akt protein, which is a downstream signaling factor that activates the PI3K pathway.

PI signaling is also regulated by the mTOR signaling pathway, which is involved in the regulation of cell growth, metabolism, and survival. The mTOR signaling pathway is activated by the recruitment of several regulatory proteins, including the mTOR protein, which is a key regulator of PI signaling.

PI signaling is regulated by several intracellular signaling pathways, including the PI3K/Akt signaling pathway, the mTOR signaling pathway, and the PI3K/Akt/mTOR signaling pathway. The PI3K/Akt signaling pathway is activated by the recruitment of several regulatory proteins, including the PI3K protein and the Akt protein, while the mTOR signaling pathway is activated by the recruitment of several regulatory proteins, including the mTOR protein.

Drugs that target PI signaling pathways have been developed as potential therapeutic agents for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. For example, the PI3K inhibitor sunitinib has been shown to have therapeutic effects against cancer and neurodegenerative diseases. Similarly, the mTOR inhibitor rapamycin has been shown to have therapeutic effects against cancer, neurodegenerative diseases, and cardiovascular diseases.

In addition to its role in cell signaling, PI is also involved in the regulation of DNA replication and cell survival. The PI3K pathway is involved in the regulation of DNA replication, as it plays a role in the loading of the replication complex onto the replicating chromosome. Additionally, PI is involved in the regulation of cell survival, as it plays a role in the regulation of cell apoptosis

Protein Name: Phosphoinositide Kinase, FYVE-type Zinc Finger Containing

Functions: Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029)

The "PIKFYVE Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PIKFYVE comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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