PIK3R4: A Potential Drug Target and Biomarker for the Treatment of Inflammatory Diseases

Target Name: PIK3R4

NCBI ID: G30849

PIK3R4

PIK3R4: A Potential Drug Target and Biomarker for the Treatment of Inflammatory Diseases

Inflammatory diseases, such as rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease (IBD), affect millions of people worldwide and cause significant morbidity and mortality. Chronic inflammation in these diseases can lead to chronic pain, decreased quality of life, and increased risk of complications. The identification of potential drug targets and biomarkers for the treatment of inflammatory diseases is crucial for the development of new, more effective therapies. In this article, we discuss PIK3R4, a potential drug target and biomarker for the treatment of inflammatory diseases.

PI3K-Inhibitors: A Review of the Literature

PI3K (phosphatidylinositol 3-kinase) is a protein that plays a crucial role in cell signaling and is involved in the regulation of many cellular processes, including inflammation. The ability of PI3K to regulate cell signaling has made it an attractive target for the development of new drugs for inflammatory diseases. Several inhibitors of PI3K have been developed and are currently in use, including:

1. Pi181-0322: This is a small molecule inhibitor of PI3K-A, which is the primary isoform of PI3K. It has been shown to be effective in animal models of rheumatoid arthritis and other inflammatory diseases.
2. AMT032221: This is a peptide inhibitor of PI3K-B, which is the only isoform of PI3K that is expressed in human tissues. It has been shown to be effective in animal models of inflammation and has been tested in human clinical trials for the treatment of inflammatory bowel disease.
3. MS-271: This is a small molecule inhibitor of PI3K-C, which is the isoform of PI3K that is expressed in many tissues, including the brain. It has been shown to be effective in animal models of anxiety and depression.

Expression and function of PIK3R4:

PI3K is a protein that is expressed in many tissues and is involved in the regulation of cellular signaling. It consists of a catalytic active site, a regulatory domain, and a catalytic domain. The regulatory domain is responsible for the regulation of PI3K-A and PI3K-B isoforms, while the catalytic domain is responsible for the catalytic activity of the enzyme.

Expression of PI3K is regulated by various factors, including phosphorylation and dephosphorylation. Phosphorylation of PI3K-A and PI3K-B isoforms can lead to increased activity and stability, while dephosphorylation can decrease activity. The expression of PI3K is also regulated by its interactions with other proteins, including Shc/YAP (a G protein-coupled receptor) and FAK (a protein that can interact with FAK/PI3K).

Inflammatory diseases are characterized by chronic inflammation, which can lead to the activation and proliferation of immune cells and the production of pro-inflammatory cytokines. The activation and proliferation of immune cells can lead to the production of pro-inflammatory cytokines, such as TNF-伪, IL-1, and IL-6, which can further exacerbate the inflammatory response. The production of pro-inflammatory cytokines can also lead to the recruitment of immune cells to sites of inflammation, such as the gut or joints, and contribute to the development of inflammatory diseases.

The ability of PI3K to regulate cell signaling has made it an attractive target for the development of new drugs for inflammatory diseases. By inhibiting PI3K activity, drugs can reduce the production of pro-inflammatory cytokines and decrease the activation and proliferation of immune cells. This can lead to the improvement of inflammatory symptoms and the reduction of the risk of complications.

Drugs that inhibit PI3K activity have been developed and are currently in use for the treatment of inflammatory diseases. These drugs work by inhibiting the

Protein Name: Phosphoinositide-3-kinase Regulatory Subunit 4

Functions: Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123)

The "PIK3R4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PIK3R4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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