SMC3: A Protein Implicated in Tissue Repair and Regeneration (G9126)

Target Name: SMC3

NCBI ID: G9126

SMC3

SMC3: A Protein Implicated in Tissue Repair and Regeneration

SMC3, also known as chondroitin sulfate proteoglycan 6 (bamacan), is a protein that is expressed in various tissues throughout the body, including articular cartilage, tendons, and ligaments. It is a key component of extracellular matrix (ECM) tissue structures and plays a crucial role in the mechanical properties of these structures. SMC3 has been shown to be involved in the regulation of cellular processes that are important for tissue repair and regeneration, and as such, it has potential as a drug target or biomarker.

SMC3 was first identified in the late 1990s as a gene that was expressed in a variety of tissues, including tendons, articular cartilage, and skin. The gene encodes a protein that is composed of multiple domains, including an N-terminal transmembrane domain, a cytoplasmic domain, and an C-terminal region that includes a conserved predicted extracellular matrix (ECM) domain. The ECM domain is composed of a repeated sequence of alanine/aspartic acid (A/A) and glutamic acid (G/A) residues, which give the protein its name.

SMC3 is a key component of the ECM, and it plays a critical role in maintaining the mechanical properties of various tissues. In articular cartilage, SMC3 is involved in the regulation of cell-cell and cell-tissue interactions, as well as the production of new cartilage cells. It is also involved in the regulation of the cytoskeleton, as it interacts with microtubules and actin filaments. In tendons and ligaments, SMC3 is involved in the regulation of cell-cell and cell-tissue interactions, as well as the production of new tendon and ligament cells.

SMC3 has also been shown to be involved in the regulation of cellular processes that are important for tissue repair and regeneration. For example, it has been shown to be involved in the regulation of cell-cell and cell-tissue interactions during the process of wound healing, as well as the regulation of the cytoskeleton during the process of muscle growth and repair. It has also been shown to play a role in the regulation of inflammation and fibrosis, processes that are important for the development and progression of various diseases, including cancer.

SMC3 has also been shown to be involved in the regulation of cellular processes that are important for the development and progression of various diseases. For example, it has been shown to be involved in the regulation of cell-cell and cell-tissue interactions during the process of cancer growth and metastasis, as well as the regulation of the cytoskeleton during the process of tumor progression. It has also been shown to play a role in the regulation of inflammation and fibrosis, processes that are important for the development and progression of various diseases, including cancer.

Due to its involvement in these processes, SMC3 has been shown to have potential as a drug target or biomarker. For example, studies have shown that inhibiting SMC3 can lead to the regression of established cancer tumors, as well as the inhibition of the development of new tumors. Additionally, studies have shown that inhibiting SMC3 can also lead to the regression of established autoimmune diseases, such as rheumatoid arthritis and insulin-dependent diabetes mellitus.

In addition to its potential as a drug target or biomarker, SMC3 is also of interest as a potential therapeutic agent for the treatment of various diseases. For example, studies have shown that SMC3 has been shown to be involved in the regulation of cellular processes that are important for the development and progression of various diseases, including cancer. As such, SMC3 may be a useful target

Protein Name: Structural Maintenance Of Chromosomes 3

Functions: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement

The "SMC3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SMC3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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