SMC5: A Protein Crucial for Maintaining Chromosomal Stability

Target Name: SMC5

NCBI ID: G23137

SMC5

SMC5: A Protein Crucial for Maintaining Chromosomal Stability

Structural maintenance of chromosomes (SMC5) is a protein that plays a crucial role in ensuring the stability and integrity of chromosomes. It helps to keep the chromosomes in their proper shape and position, which is essential for the proper functioning of the cell. SMC5 is also involved in the regulation of gene expression, and it has been linked to a number of diseases, including cancer. As a result, SMC5 has become a focus of interest for researchers as a potential drug target or biomarker.

SMC5 is a member of the SMC family of proteins, which are known for their role in maintaining chromosomal stability. Chromosomes are the genetic material that makes up the chromosomes, and they are composed of a protein called DNA and a protein called histone. replicated before cell division, and they are also subject to repair and degradation. SMC5 is one of the proteins that helps to maintain the stability and integrity of chromosomes.

SMC5 helps to ensure that chromosomes remain in their proper shape and position. It does this by playing a role in the regulation of the mechanical forces that are exerted on the chromosomes. SMC5 helps to keep the chromosomes flexible and resilient, which allows them to withstand the stresses of replication and transcription. It also helps to keep the chromatin compact and organized, which allows for the proper expression of genes.

SMC5 is also involved in the regulation of gene expression. It does this by interacting with a protein called silencing factor silencing element (SFED), which is located on the DNA of the chromosome. SFED is responsible for repressing the expression of genes that are not needed during periods of cell growth, such as when the cell is dividing. SMC5 helps to keep SFED active, which allows for the expression of genes that are necessary for the cell to grow and divide properly.

SMC5 has also been linked to a number of diseases, including cancer. Studies have shown that SMC5 is often overexpressed in cancer cells, and that this overexpression is associated with a number of negative outcomes, including the development of drug resistance and the progression of cancer . Therefore, SMC5 has become a focus of interest for researchers as a potential drug target or biomarker.

In addition to its role in maintaining chromosomal stability and gene expression, SMC5 is also involved in the regulation of cellular processes that are important for the survival of the cell. It helps to keep the cell nucleus in its proper shape and position, which is essential for the proper functioning of the cell. SMC5 also helps to keep the cell membrane stable, which is essential for the proper delivery of nutrients and oxygen to the cells.

SMC5 is also involved in the regulation of cellular processes that are important for the development and maintenance of tissues. It helps to keep the cell cytoskeleton in its proper shape and position, which is essential for the proper formation of tissues and organs. to keep the cell plasma membrane stable, which is essential for the proper communication between the cell and its surroundings.

In conclusion, SMC5 is a protein that plays a crucial role in maintaining the stability and integrity of chromosomes. It helps to keep the chromosomes in their proper shape and position, which is essential for the proper functioning of the cell. SMC5 is also involved in the regulation of gene expression and is associated with a number of diseases, including cancer. As a result, SMC5 has become a focus of interest for researchers as a potential drug target or biomarker. Further research is needed to fully understand the role of SMC5 in cellular processes and to develop effective treatments for the diseases associated with its dysfunction.

Protein Name: Structural Maintenance Of Chromosomes 5

Functions: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541)

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