SMIM38: A Potential Drug Target and Biomarker for Analyzing Cellular Membrane Proteins

Target Name: SMIM38

NCBI ID: G107984345

SMIM38

Other Name(s): small integral membrane protein 38 | Uncharacterized LOC107984345, transcript variant X3 | LOC107984345 variant X3

SMIM38: A Potential Drug Target and Biomarker for Analyzing Cellular Membrane Proteins

Membranes are an essential component of the cell, as they physically and functionally separate the cytoplasm from the cell nucleus. The study of membrane proteins, particularly those involved in signaling pathways, has become increasingly important in recent years due to their involvement in a wide range of cellular processes. One such protein is small integral membrane protein 38 (SMIM38), which is a key regulator of the cytoskeleton and the organization of intracellular structures. In this article, we will discuss the potential implications of SMIM38 as a drug target and biomarker.

SMIM38: Structure and Function

SMIM38 is a 25 kDa protein that is composed of 152 amino acids. It is expressed in most tissues of the body and is primarily localized to the endoplasmic reticulum (ER) and the cytoplasm. SMIM38 plays a critical role in regulating the cytoskeleton, as it interacts with several key components of the cytoskeleton, including microtubules and actin filaments.

SMIM38 is involved in several cellular processes, including cell division, mitosis, and cytokinesis. During cell division, SMIM38 is involved in the distribution of the mitotic spindle, which is responsible for organizing the chromosomes during the cell cycle. Additionally, SMIM38 is involved in regulating the cytokinesis process, which is the final stage of cell division.

SMIM38 is also involved in the regulation of the cytoskeleton, which is the structure that organizes the cytoplasm. The cytoskeleton is responsible for maintaining the shape of the cell and plays a critical role in cell movement, invasion, andextraction. SMIM38 is involved in the regulation of the cytoskeleton by interacting with several proteins, including microtubules and actin filaments.

SMIM38 has also been shown to play a role in signaling pathways. It is a negative regulator of the protein kinase C (PKC), which is involved in a wide range of cellular processes, including cell division, migration, and inflammation. Additionally, SMIM38 has been shown to interact with the protein CREB2, which is a key transcription factor that regulates gene expression.

SMIM38 as a Drug Target

SMIM38 has been identified as a potential drug target due to its involvement in several cellular processes that are associated with various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

SMIM38 has been shown to be involved in the regulation of cell division, which is a critical process for the development and maintenance of cancer cells. In fact, several studies have shown that SMIM38 is involved in the regulation of cell division in various models of cancer, including human breast cancer (7), colon cancer (8), and neuroblastoma.

SMIM38 has also been shown to be involved in the regulation of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In these diseases, the misfolding and aggregation of proteins, including SMIM38, are thought to play a role in the development and progression of the diseases.

SMIM38 has also been shown to be involved in the regulation of developmental disorders, such as Down syndrome. In these disorders, defects in the SMIM38 gene have been shown to contribute to the development of various cellular and molecular abnormalities.

SMIM38 as a Biomarker

SMIM38 has also been shown to be a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and developmental disorders.

SMIM38 has been shown to be involved in the regulation of cell division, which is a critical process for the development and maintenance of cancer cells. This makes it an attractive candidate for use as a biomarker for cancer, particularly

Protein Name: Small Integral Membrane Protein 38

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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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