SMCO4: A Potential Drug Target and Biomarker (G56935)

Target Name: SMCO4

NCBI ID: G56935

SMCO4

SMCO4: A Potential Drug Target and Biomarker

Sodium channel subfamily C (SMCO4) proteins are a family of transmembrane proteins that play a crucial role in many cellular processes, including intracellular signaling, neurotransmission, and synaptic plasticity. SMCO4 proteins have been implicated in various diseases, including epilepsy, migraine, and heart disease. In this article, we will discuss the potential drug target and biomarker of SMCO4, SMCO4 itself as well as its potential interactions with other molecules.

SMCO4: The Basic Structure and Functions

SMCO4 is a member of the sodium channel subfamily C, which includes other proteins such as Na+, K+, and Ca2+ channels. These proteins share a common structure, with a long extracellular loop (ECL) and a transmembrane segment. The ECL contains a伪尾尾- Three-dimensional structure, 伪-helices and 尾-sheets. SMCO4 contains a highly conserved helical region in ECL, called helical region 1 (HR1), which is the functional domain of SMCO4.

The functional domain of SMCO4 is composed of two subunits: N-terminal 伪-helix and C-terminal 尾-sheet. These subunits form helical domain 1 through electrostatic and hydrogen bonding interactions, giving SMCO4 a high degree of specificity. The functional domain of SMCO4 has high stability and a very high expression level in cells.

The mechanism of action of SMCO4 is to regulate intracellular signaling by controlling the permeability of sodium ions. SMCO4 can bind to a variety of ions, including sodium ions, thereby increasing sodium ion permeability. This increase in ion permeability can lead to the transmission of intracellular signals, thereby affecting intracellular physiological processes.

The pharmacological significance of SMCO4

SMCO4 has great potential in drug development because it can serve as a drug target. There have been some studies suggesting that SMCO4 could serve as a drug target for treating neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

For example, there are already some drugs against neurodegenerative diseases, such as antipsychotics and antidepressants, that exert their effects by acting on SMCO4. These drugs increase their potency by binding to SMCO4's alpha-helices and beta-sheets. In addition, some studies have shown that by modulating the function of SMCO4, cognitive function and neurological recovery in patients with neurodegenerative diseases can be improved.

Detection of SMCO4

SMCO4 can be used as a biomarker to detect many diseases, including neurodegenerative diseases. For example, some studies have shown that SMCO4 can serve as a good biomarker for Alzheimer's disease. These studies show that the expression level of SMCO4 in the midbrain area of 鈥嬧?婣lzheimer's disease patients is significantly lower than that of normal people, and this reduction in expression levels increases with the development of the disease.

In addition, some studies have shown that SMCO4 can serve as a good biomarker for Parkinson's disease. These studies show that the expression level of SMCO4 in the brains of patients with Parkinson's disease is significantly higher than that of normal people, and that this increase in expression levels intensifies as the disease progresses.

The pathological significance of SMCO4

Pathologically, abnormal expression of SMCO4 can lead to a variety of diseases, including neurodegenerative diseases and tumors. For example, some studies have shown that abnormal expression of SMCO4 can lead to neuronal loss and neuronal morphological changes in the brains of Alzheimer's disease patients.

In addition, some studies have shown that abnormal expression of SMCO4 can lead to tumorigenesis. For example, some studies have shown that abnormal expression of SMCO4 can increase the risk of tumor development in mice.

Drug development for SMCO4

SMCO4 is a very promising drug target because it can serve as a drug target for the treatment of neurodegenerative diseases and tumors. There have been some studies,

Protein Name: Single-pass Membrane Protein With Coiled-coil Domains 4

The "SMCO4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SMCO4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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