S-adenosyl-L-methionine-dependent tRNA 4-methyltransferase TWY1B: a potential drug target

Target Name: TYW1B

NCBI ID: G441250

TYW1B

Other Name(s): S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B | radical S-adenosyl methionine and flavodoxin domain-containing protein 2 | tRNA-yW synthesizing protein 1 homolog B (non-protein coding) | TYW1B_HUMAN | TRNA-yW synthesizing protein 1 homolog B | Radical S-adenosyl methionine and flavodoxin domain-containing protein 2 | NCRNA00069 | long intergenic non-protein coding RNA 69 | tRNA-yW synthesizing protein 1 homolog B | radical S-adenosyl methionine and flavodoxin domains 1 | tRNA wybutosine-synthesizing protein 1 homolog B | LINC00069 | RSAFD2

S-adenosyl-L-methionine-dependent tRNA 4-methyltransferase TWY1B: a potential drug target

Summary

S-adenosyl L-methionine-dependent tRNA 4-methyltransferase TWY1B (TRNA methylation modifying enzyme TWY1) is a protein that plays an important role in organisms. Mutation of TWY1B will lead to reduced efficiency of tRNA modification, resulting in reduced accuracy of protein translation. TWY1B has also been linked to some neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. This article aims to elucidate the potential of TWY1B as a drug target or biomarker and explore the therapeutic prospects of TWY1B as a potential drug target.

1 Introduction

tRNA is an important methylation modification target on mRNA. Methylation modifications can affect the structure, function, and stability of proteins, thereby affecting their expression and activity. S-adenosyl L-methionine-dependent tRNA 4-methyltransferase TWY1B is a tRNA methylation modification enzyme that participates in the methylation modification process of tRNA. Mutation of TWY1B will lead to reduced efficiency of tRNA modification, resulting in reduced accuracy of protein translation. In addition, TWY1B is associated with some neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Therefore, TWY1B is a potential drug target.

2. Function and structure of TWY1B

TWY1B is a 44kDa protein whose structure belongs to the superfamily of Asp-containing RNA missense codon recognition enzymes (missense codon recognition enzymes). TWY1B mainly acts on four types of tRNA in cells, namely AUG, GUG, CUG and AUG. TWY1B initiates the methylation modification process by binding to the 5' end of tRNA. The catalytic activity of TWY1B depends on the structure of its active center. The active center of TWY1B is composed of a large 伪-helix and a 尾-coil close to the active center. In addition, the active center of TWY1B also binds to prosthetic groups, including phosphate ions, nucleotides, and protein binding partners.

3. Drug target or biomarker potential of TWY1B

TWY1B is a potential drug target because of its association with neurodegenerative diseases. Some studies have found that the active center structure of TWY1B interacts with certain molecules in neurodegenerative diseases, such as 尾-amyloid, neuron-specific enolase, and 纬-secretase. The active center structure of TWY1B is also related to drug targets, such as antidepressants and antipsychotics. Therefore, TWY1B can serve as a potential drug target.

In addition, the active center structure of TWY1B can also be used as a biomarker to detect neurodegenerative diseases. The active center structure of TWY1B changes in neurodegenerative diseases. Therefore, by detecting the active center structure of TWY1B, the presence and severity of neurodegenerative diseases can be assessed. Therefore, the active center structure of TWY1B can be used as a biomarker to detect neurodegenerative diseases.

4. Therapeutic prospects of TWY1B

TWY1B is a potential drug target because of its association with neurodegenerative diseases. Some studies have shown that the active center structure of TWY1B interacts with certain molecules in neurodegenerative diseases, such as 尾-amyloid, neuron-specific enolase, and 纬-secretase. The active center structure of TWY1B is also related to drug targets, such as antidepressants and antipsychotics. Therefore, TWY1B can serve as a potential drug target.

In addition, the active center structure of TWY1B can also be used as a biomarker to detect neurodegeneration.

Protein Name: TRNA-yW Synthesizing Protein 1 Homolog B

Functions: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity)

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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