SHKBP1: A Potential Drug Target and Biomarker (G92799)

Target Name: SHKBP1

NCBI ID: G92799

SHKBP1

SHKBP1: A Potential Drug Target and Biomarker

SHKBP1, also known as SETA-binding protein 1, is a protein that is expressed in various tissues throughout the body. It plays a crucial role in the regulation of cell proliferation and differentiation, and is associated with various diseases, including cancer. In recent years, researchers have been interested in investigating the potential drug targets and biomarkers associated with SHKBP1.

SHKBP1 is a member of the SAS-30 family of proteins, which are known for their ability to interact with and regulate the activity of other proteins. The SAS-30 family includes four isoforms, including SHKBP1, SHKBP2, SHKBP3, and SHKBP4. These proteins are involved in various cellular processes, including cell adhesion, migration, and signaling pathways.

SHKBP1 is expressed in various tissues, including the brain, heart, liver, and kidney. It is involved in the regulation of cell proliferation, differentiation, and survival. Studies have shown that SHKBP1 is highly expressed in cancer tissues and is associated with poor prognosis in cancer patients.

In addition to its involvement in cancer, SHKBP1 is also associated with a number of other diseases. For example, it is involved in the regulation of cell migration and has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. It is also involved in the regulation of cell adhesion and has been shown to be involved in the development of various diseases, including cancer and neurodevelopmental disorders.

Despite its involvement in a number of diseases, SHKBP1 has not yet been identified as a potential drug target or biomarker. However, recent studies have identified potential drug targets and biomarkers associated with SHKBP1.

One potential drug target associated with SHKBP1 is the protein p180, which is a validated drug target for SHKBP1. p180 is a protein that is expressed in various tissues and is involved in the regulation of cell proliferation and survival. Studies have shown that SHKBP1 and p180 can interact and that inhibition of SHKBP1 activity can lead to decreased p180 activity. This suggests that p180 may be an attractive drug target for SHKBP1.

Another potential drug target associated with SHKBP1 is the protein SMAD4, which is involved in the regulation of cell proliferation and apoptosis. Studies have shown that SHKBP1 and SMAD4 can interact and that inhibition of SHKBP1 activity can lead to decreased SMAD4 activity. This suggests that SMAD4 may be an attractive drug target for SHKBP1.

In addition to potential drug targets, SHKBP1 has also been identified as a potential biomarker for a number of diseases. For example, SHKBP1 has been shown to be involved in the regulation of cell adhesion and has been associated with the development of various diseases, including cancer. Additionally, SHKBP1 has been shown to be involved in the regulation of cell migration and has been associated with the development of neurodegenerative diseases.

Overall, SHKBP1 is a protein that is involved in various cellular processes and has been associated with a number of diseases. While it is not yet clear what the ultimate drug target or biomarker for SHKBP1 will be, it is clear that SHKBP1 is an attractive candidate for further investigation. Further studies are needed to fully understand the role of SHKBP1 in various diseases and to identify potential drug targets and biomarkers associated with this protein.

Protein Name: SH3KBP1 Binding Protein 1

Functions: Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation

The "SHKBP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SHKBP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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