SIRT5: A Protein Involved in Cellular Processes That Impact Aging and Age-related Diseases

Target Name: SIRT5

NCBI ID: G23408

SIRT5

SIRT5: A Protein Involved in Cellular Processes That Impact Aging and Age-related Diseases

SIRT5, or NAD-dependent protein deacylase sirtuin-5, is a protein that is expressed in most tissues of the body and is involved in a variety of cellular processes. It is a key player in the DNA damage repair pathway, which helps to protect the cell from the harmful effects of mutations that can occur during DNA replication. SIRT5 is also involved in the regulation of cellular processes such as cell growth, apoptosis, and inflammation.

One of the unique features of SIRT5 is its dependence on NAD (nicotinamide adenine dinucleotide), a molecule that is involved in a variety of cellular processes. NAD is a crucial cofactor for many enzymes, including those that participate in the DNA damage repair pathway. By participating in this pathway, SIRT5 is able to repair damage to DNA and protect the cell from the harmful effects of mutations.

SIRT5 is a protein that is often targeted by drugs because of its involvement in a variety of cellular processes that are associated with aging and age-related diseases. For example, SIRT5 has been shown to be involved in the regulation of cellular processes that are associated with aging, such as the accumulation of harmful mutations in DNA.

In addition to its role in the DNA damage repair pathway, SIRT5 is also involved in the regulation of cellular processes that are associated with inflammation. This is because SIRT5 is a key player in the production of reactive oxygen species (ROS), which are highly reactive molecules that can cause damage to cellular components and contribute to inflammation.

SIRT5 is also involved in the regulation of cellular processes that are associated with cell death, which is a crucial part of the process of aging. SIRT5 has been shown to play a key role in the regulation of cell death, which is a normal part of the aging process.

In addition to its role in the regulation of cell death, SIRT5 is also involved in the regulation of cellular processes that are associated with muscle mass and strength. This is because SIRT5 is involved in the production of muscle protein, which is essential for maintaining muscle mass and strength.

SIRT5 is also involved in the regulation of cellular processes that are associated with the immune system. This is because SIRT5 is a key player in the production of immune cells, which are essential for maintaining a healthy immune system.

In conclusion, SIRT5 is a protein that is involved in a variety of cellular processes that are important for maintaining the health and function of the cell. Its dependence on NAD and its role in the regulation of DNA damage repair, inflammation, cell death, muscle mass and strength, and the immune system make it an attractive target for drug development.

Protein Name: Sirtuin 5

Functions: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX

The "SIRT5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SIRT5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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