SHLD3: A Potential Drug Target and Biomarker (G112441434)

Target Name: SHLD3

NCBI ID: G112441434

SHLD3

SHLD3: A Potential Drug Target and Biomarker

Shieldin complex subunit 3 (SHLD3) is a protein that is expressed in various tissues and cell types in the human body. It is a key component of the shieldin complex, a protein complex that plays a critical role in maintaining cellular membrane structure and functions. The shieldin complex is composed of four subunits: SHLD1, SHLD2, SHLD3, and SHLD4. SHLD3 is one of the four subunits that share a similar molecular sequence, but it has unique functions in the cell.

The shieldin complex is involved in many cellular processes that are essential for cell survival and proper function. One of the most important functions of the shieldin complex is to maintain the integrity of the cell membrane. The membrane is a critical barrier that separates the cell from the surrounding environment and regulates the passage of substances into and out of the cell. The shieldin complex helps to maintain the stability of the cell membrane by interacting with various components on the surface of the cell.

One of the unique features of SHLD3 is its ability to interact with the cytoplasmic side of the cell membrane. This interaction is critical for the development of cancer, as changes in the cytoplasmic side of the cell membrane can contribute to the development of cancer cells. Researchers have shown that changes in the expression and function of SHLD3 can promote the development of various types of cancer, including breast, ovarian, and prostate cancer.

In addition to its role in cell membrane structure and function, SHLD3 is also a potential drug target. Many studies have shown that SHLD3 can interact with various signaling molecules, including TGF-β1, which is a well-known growth factor that plays a critical role in cell growth, differentiation, and survival. TGF-β1 signaling is involved in many cellular processes that are important for cell survival, including cell proliferation, migration, and invasion.

Research has also shown that SHLD3 can interact with the protein p16INK4a, which is a negative regulator of the TGF-β1 signaling pathway. This interaction between SHLD3 and p16INK4a suggests that SHLD3 may be a potential drug target for diseases that are caused by the over- activity of the TGF-β1 signaling pathway.

Another potential drug target for SHLD3 is its role in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles, which are thought to be caused by the over- activity of the TGF-β1 signaling pathway.

Research has shown that SHLD3 can interact with the protein SNAPP/Nrf, which is involved in the detoxification of harmful substances in the brain. The Nrf gene is a well-known gene that is involved in the detoxification of various harmful substances, including radiation and oxidative stress. The interaction between SHLD3 and SNAPP/Nrf suggests that SHLD3 may be a potential drug target for neurodegenerative diseases.

In conclusion, SHLD3 is a protein that is involved in many cellular processes that are essential for cell survival and proper function. Its unique ability to interact with the cytoplasmic side of the cell membrane and its potential as a drug target make it an attractive target for the development of new therapies for various diseases. Further research is needed to fully understand the role of SHLD3 in cellular processes and its potential as a drug target.

Protein Name: Shieldin Complex Subunit 3

Functions: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres

The "SHLD3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SHLD3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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