SKA1: A Potential Drug Target and Biomarker for Spindle-Induced Anemia

Target Name: SKA1

NCBI ID: G220134

SKA1

SKA1: A Potential Drug Target and Biomarker for Spindle-Induced Anemia

Spindle-induced anemia (SIA) is a type of anemia that occurs in individuals with spina muscular atrophy, a genetic disorder that affects muscle strength and function. The pathological hallmark of SIA is the loss of muscle mass and strength, which is often accompanied by anemia. SIA is a serious and life-threatening condition that affects approximately 10,000 individuals worldwide, and there is currently no effective treatment available.

The spindle protein is a key regulator of microtubules, which are the structural elements that organize and transport genetic material in the nucleus of a cell. The loss of microtubules can lead to the misfolding of nuclear proteins and the formation of aggregates that can cause various cellular pathologies, including SIA.

SKA1, a gene encoding a protein that is involved in the regulation of microtubules, has been identified as a potential drug target and biomarker for SIA. In this article, we will discuss the SKA1 protein, its function in microtubule regulation, its potential as a drug target, and its potential as a biomarker for SIA.

Function of SKA1 in Microtubule Regulation

SKA1 is a 21-kDa protein that is expressed in a variety of tissues, including muscle, brain, and heart. It is involved in the regulation of microtubules and is thought to play a role in the maintenance of the cytoskeleton and the organization of cellular structures.

SKA1 is a key regulator of the stability of microtubules, which are composed of two interacting subunits: the alpha-tubulin protein and the beta-tubulin protein. alpha-tubulin is the major subunit of microtubules and is responsible for the structural stability of the microtubules, while beta-tubulin is the minor subunit that binds to alpha-tubulin and adds stability to the microtubules.

SKA1 interacts with the alpha-tubulin protein and is thought to play a role in the regulation of the stability of microtubules. It does this by interacting with the alpha-tubulin protein and promoting the formation of a higher-energy state microtubule. This higher-energy state microtubule is more stable and less prone to collapse, which can lead to the retention of nuclear proteins in the cytoplasm and the formation of aggregates that can cause SIA.

Potential as a Drug Target

SKA1 has been identified as a potential drug target for SIA due to its involvement in the regulation of microtubules. Microtubules are thought to play a key role in the regulation of cellular processes that are important for the development and maintenance of the neuromuscular system, and alterations in microtubule structure and stability can contribute to the pathophysiology of SIA.

SKA1 has been shown to play a role in the regulation of microtubule stability in various cell types, including muscle and heart cells. By modulating the stability of microtubules, SKA1 has been shown to influence the contractility and relaxation of muscle cells and contribute to the pathophysiology of SIA.

In addition, SKA1 has also been shown to play a role in the regulation of microtubule stability in the brain, where it is thought to contribute to the organization and stability of the neuronal cytoskeleton.

Biomarker for SIA

SKA1 has also been identified as a potential biomarker for SIA due to its involvement in the regulation of microtubule stability. The loss of microtubules is a hallmark of SIA, and changes in microtubule stability can be detected using various techniques, including Western blotting, immunofluorescence, and biochemical assays.

SKA1 has been shown to be expressed in muscle and heart cells and has been shown to play a role in the regulation of microtubule stability in these cell types. It has also been shown to be involved in the regulation of microtubule stability in the brain, where it is thought to contribute to the

Protein Name: Spindle And Kinetochore Associated Complex Subunit 1

Functions: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:19289083, PubMed:23085020)

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