SKA2: Potential Drug Targets and Biomarkers (G348235)

Target Name: SKA2

NCBI ID: G348235

SKA2

SKA2: Potential Drug Targets and Biomarkers

SKA2 (Sequence Similarity 33) is a protein that is expressed in various tissues throughout the body. It is a key regulator of cell signaling pathways and has been implicated in a number of diseases, including cancer. In this article, we will explore the potential drug targets and biomarkers associated with SKA2.

SKA2 is a member of the SKA family of proteins, which are known for their role in regulating cell signaling pathways. The SKA family consists of four proteins: SKA1, SKA2, SKA3, and SKA4. These proteins share a conserved catalytic core and a similar overall structure, but they differ in their sequence and/or post-translational modification.

SKA2 is a 21-kDa protein that is expressed in various tissues, including muscle, heart, brain, and cancer. It is involved in the regulation of several different signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway.

One of the key functions of SKA2 is its role in the regulation of cell proliferation. SKA2 has been shown to play a negative role in the growth and survival of various cancer cell lines. In addition, SKA2 has been shown to promote the growth of brain cancer cells, a finding that may have implications for the development of new treatments for these deadly diseases.

Another function of SKA2 is its role in the regulation of cell signaling pathways. SKA2 has been shown to play a negative role in the regulation of several different signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. These pathways are involved in the regulation of cell growth, differentiation, and survival, and are important for the development and maintenance of tissues and organs.

In addition to its role in cell signaling pathways, SKA2 is also involved in the regulation of several other cellular processes. For example, SKA2 has been shown to play a negative role in the regulation of cell migration and the maintenance of cell-cell adhesion. These processes are important for the development and maintenance of tissues and organs, and are implicated in a number of diseases, including cancer.

SKA2 has also been shown to play a role in the regulation of inflammation. SKA2 has been shown to promote the production of pro-inflammatory cytokines, such as TNF-伪 and IL-8, in response to different stimuli. This finding may have implications for the development of new treatments for inflammatory diseases.

In conclusion, SKA2 is a protein that is involved in the regulation of several different cellular processes, including cell signaling pathways, cell proliferation, and inflammation. As a result, SKA2 may be a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of SKA2 in these processes and to develop new treatments for these diseases.

Protein Name: Spindle And Kinetochore Associated Complex Subunit 2

Functions: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020)

The "SKA2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SKA2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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