CHD1L: Chromatin-Remodeling Complex Member Involved in DNA Replication, Transcription and Cell Growth

Target Name: CHD1L

NCBI ID: G9557

CHD1L

CHD1L: Chromatin-Remodeling Complex Member Involved in DNA Replication, Transcription and Cell Growth

Chromodomain-helicase-DNA-binding protein 1-like (CHD1L) is a protein that plays a crucial role in the regulation of DNA replication and repair. It is a member of the chromatin-remodeling complex, which is responsible for the maintenance of the structural integrity of the chromome during DNA replication and repair. CHD1L is essential for the proper functioning of this complex and is involved in the regulation of numerous cellular processes, including DNA replication, transcription, and gene expression.

CHD1L is a protein that is composed of 21 kDa, and it contains a unique domain that is specific for DNA binding. This domain is known as the \"helicase domain\" and is responsible for the protein's ability to bind to DNA. The helicase domain is composed of a specific sequence of amino acids that is responsible for the formation of a right-handed structure that is able to recognize and bind to specific sequences of DNA.

CHD1L is also known for its role in the regulation of DNA replication. During DNA replication, CHD1L is involved in the formation of a double helix and is thought to play a key role in the regulation of the hands of the double helix. This is done by the way it interacts with the DNA template, where it is able to form a stable complex with the template and prevent the dissociation of the replication fibers.

In addition to its role in DNA replication, CHD1L is also involved in the regulation of transcription. It is known to play a key role in the regulation of gene expression by binding to specific DNA sequences. This is done by the way it interacts with the RNA polymerase, which is responsible for transcribing the DNA template into RNA.

CHD1L is also involved in the regulation of cell growth and division. It is known to play a key role in the regulation of the cell cycle, and it is thought to be involved in the G1 phase of the cell cycle. During the G1 phase, CHD1L is thought to play a key role in the regulation of protein synthesis and cell growth.

CHD1L is also involved in the regulation of inflammation. It is known to play a key role in the regulation of inflammation and is thought to be involved in the regulation of the immune response.

In conclusion, CHD1L is a protein that is involved in a number of important cellular processes, including DNA replication, transcription, and cell growth and division. It is also involved in the regulation of inflammation and is thought to be a potential drug target or biomarker . Further research is needed to fully understand the role of CHD1L in these processes and to determine its potential as a drug.

Protein Name: Chromodomain Helicase DNA Binding Protein 1 Like

Functions: ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:33357431, PubMed:34486521, PubMed:34874266, PubMed:34210977). Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34874266, PubMed:34486521). Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34874266, PubMed:34486521). Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner (PubMed:19661379, PubMed:29220652, PubMed:29220653). Chromatin remodeling activity promotes PARP2 removal from chromatin (PubMed:33275888)

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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