CHM: A Protein Involved in Cell Signaling and Stability (G1121)

Target Name: CHM

NCBI ID: G1121

Content of Review Report on CHM Target / Biomarker

CHM

CHM: A Protein Involved in Cell Signaling and Stability

CHM, or Rab proteins geranylgeranyltransferase component A 1 (isoform a), is a protein that is expressed in a variety of tissues throughout the body, including the brain, heart, and kidneys. It is a key component of the retina, where it plays a role in the structure and function of photoreceptor cells.

CHM is made up of two distinct isoforms, A and B, which are produced by alternative splicing of the gene. Both isoforms are involved in the transfer of geranylgeranyl, a modified amino acid that is derived from the amino acid cysteine, to other proteins. This transfer of geranylgeranyl is a critical step in the production of proteins with modified amino acids, which can have a number of different functions, including modulating protein stability, localization, and interactions with other molecules.

One of the key functions of CHM is its role in modulating the stability of proteins. Many proteins that are involved in signaling pathways and other critical processes in the body are modified withgeranylgeranyl, which can affect their stability and localization to specific areas of the body. CHM plays a key role in transferring this modified amino acid to other proteins, which helps to maintain the stability and integrity of these proteins.

Another important function of CHM is its role in modulating protein interactions. Many proteins that are involved in signaling pathways and other critical processes in the body interact with one another to produce specific effects. These interactions can be influenced by the presence of modified amino acids, such as geranylgeranyl. CHM plays a key role in transferring modified amino acids to other proteins, which can help to modulate these interactions and determine the overall structure and function of the proteins involved.

In addition to its role in modulating protein stability and interactions, CHM is also involved in the regulation of a variety of cellular processes, including cell signaling, cell adhesion, and cell migration. It is a key component of many signaling pathways that are involved in these processes, and its absence or dysfunction can have a negative impact on the proper functioning of the cell.

As a potential drug target, CHM is an attractive target for researchers because of its involvement in a variety of cellular processes that are involved in the development and maintenance of health and disease. Its role in modulating protein stability, interactions, and regulation of cellular processes makes it an attractive target for the development of new therapies for a variety of diseases, including neurodegenerative disorders, cancer, and cardiovascular disease.

In conclusion, CHM, or Rab proteins geranylgeranyltransferase component A 1 (isoform a), is a protein that is involved in a variety of cellular processes that are essential for the proper functioning of the body. Its role in modulating protein stability, interactions, and regulation of cellular processes makes it an attractive target for the development of new therapies for a variety of diseases. Further research is needed to fully understand the functions of CHM and its potential as a drug target.

Protein Name: CHM Rab Escort Protein

Functions: Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation

The "CHM Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CHM comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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