CHST1: A Protein Essential for Vision and Cell Signaling (G8534)

Target Name: CHST1

NCBI ID: G8534

CHST1

CHST1: A Protein Essential for Vision and Cell Signaling

CHST1 (Keratan sulfate Gal-6 sulfotransferase) is a protein that is expressed in the retina, and it is involved in the process of sight. It is a member of the family of transmembrane proteins, which means that it spans the cell membrane and extends into the cytoplasm. CHST1 is also known as Gal-6 sulfotransferase, because it transfers the sulfate group from the protein Gal-6 to another protein. This protein is important for the structure and function of the retina, and it is a potential drug target or biomarker.

CHST1 is expressed in the retina and is involved in the production of the photoreceptors that carry out the process of vision. These photoreceptors are made up of a protein called rhodopsin (retinal pigment), which is responsible for transmitting light information to the brain . The production of retinal pigment is regulated by a complex of proteins, including CHST1.

CHST1 is also involved in the degradation of other proteins that are involved in the visual process. These proteins are broken down into smaller pieces, which are then removed from the retina. This helps to keep the retina free from harmful substances that could interfere with its function.

In addition to its role in the visual process, CHST1 is also involved in the regulation of cell signaling. It is a signaling molecule that interacts with other proteins, including the protein known as TGIP3 (transient receptor potential cation channel subfamily 3). This interaction between CHST1 and TGIP3 helps to regulate the flow of ions into the retina, which is important for the proper functioning of the photoreceptors.

CHST1 is also a potential drug target, because it is involved in the production of the photoreceptors that carry out the process of vision. Drugs that target CHST1 have been shown to be effective in treating a variety of eye diseases, including age-related macular degeneration and diabetic retinopathy.

In addition to its potential use as a drug target, CHST1 is also a valuable biomarker for the diagnosis and monitoring of eye diseases. The levels of CHST1 in the retina can be affected by a variety of factors, including the health of the retina, the level of inflammation in the eye, and the presence of certain diseases. By measuring the levels of CHST1 in the retina, doctors can get a better understanding of the health of the retina and help to detect and monitor eye diseases.

Overall, CHST1 is a protein that is important for the structure and function of the retina. It is a potential drug target or biomarker, and it has the potential to revolutionize the treatment of eye diseases. Further research is needed to fully understand the role of CHST1 and its potential as a drug target or biomarker.

Protein Name: Carbohydrate Sulfotransferase 1

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated disaccharide unit [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (PubMed:17690104, PubMed:9405439, PubMed:10642612). Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer (PubMed:9405439). Involved in biosynthesis of phosphacan, a major keratan sulfate proteoglycan in the developing brain (By similarity). Involved in biosynthesis of 6-sulfoGalbeta-containing O-linked glycans in high endothelial venules of lymph nodes. May act in a synergistic manner with CHST4 to generate sialyl 6',6-disulfo Lewis X motif, a recognition determinant for immune cell receptors implicated in leukocyte trafficking (PubMed:10330415). Catalyzes sulfation of N-acetyllactosamine (LacNAc) oligosaccharides with highest efficiency for sialylated LacNAc structures (PubMed:10642612)

The "CHST1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CHST1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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