CHMP4A: A Potential Drug Target for Neurodegenerative Diseases

Target Name: CHMP4A

NCBI ID: G29082

CHMP4A

CHMP4A: A Potential Drug Target for Neurodegenerative Diseases

CHMP4A (Snf7-1), a protein found in various cell types, including neurons and immune cells, has been identified as a potential drug target or biomarker in the field of neurodegenerative diseases. Its unique structure and function have made it an attractive target for researchers to study and develop new treatments.

CHMP4A, also known as CSN4A, is a protein that belongs to the family of nucleosome-remodeling proteins, which are responsible for the organization and disassembly of chromatin. It is a key component of the nuclear envelope, which surrounds the nuclear chromosomes and plays a crucial role in maintaining the integrity of the cell's genetic material.

CHMP4A is expressed in various cell types, including neurons, immune cells, and testes. It is highly expressed in the brain, and its levels are decreased in neurodegenerative diseases. Its reduced expression is associated with the misfolding and aggregation of neurotransmitter-producing neurons, which is a hallmark of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.

The unique structure of CHMP4A has also made it an attractive target for researchers to study the mechanisms of neurodegenerative diseases. The protein has a unique fusiform structure, with a long and narrow neck that ends in a bulbous shape. This structure is thought to play a role in the regulation of chromatin remodeling and the formation of neurotransmitter-producing neurons.

CHMP4A has also been shown to be involved in the regulation of the immune response. It is a key component of the complement system, which is responsible for the regulation of the immune response. The complement system plays a crucial role in the immune response by helping to neutralize toxins and pathogens that have entered the body.

In addition to its role in the immune response, CHMP4A has also been shown to be involved in the regulation of cell death. It is a key component of the cell death signaling pathway, which is responsible for the regulation of cell death in response to various stimuli, including stress, nutrient deprivation, and UV radiation.

The potential drug target status of CHMP4A is due to its unique structure and function, as well as its involvement in the regulation of various cellular processes. Its potential as a drug target makes it an attractive target for researchers to study the mechanisms of neurodegenerative diseases and to develop new treatments.

In conclusion, CHMP4A is a protein that has been identified as a potential drug target or biomarker in the field of neurodegenerative diseases. Its unique structure and function, as well as its involvement in the regulation of various cellular processes, make it an attractive target for researchers to study the mechanisms of neurodegenerative diseases and to develop new treatments. Further research is needed to fully understand the potential of CHMP4A as a drug target and to develop effective treatments for neurodegenerative diseases.

Protein Name: Charged Multivesicular Body Protein 4A

Functions: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413)

The "CHMP4A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CHMP4A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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