CHFR: A Potential Drug Target and Biomarker (G55743)

Target Name: CHFR

NCBI ID: G55743

CHFR

CHFR: A Potential Drug Target and Biomarker

CHFR (CHFR variant 3) is a protein that is expressed in the liver and has been shown to play a role in the regulation of cell growth and differentiation. CHFR is a member of the T-cell signaling pathway, which is a critical pathway involved in the regulation of immune and inflammatory responses. There is ongoing research into the potential uses of CHFR as a drug target or biomarker, which could lead to new treatments for a variety of diseases.

CHFR variant 3 and its function

CHFR is a 22-kDa transmembrane protein that is expressed in the liver, heart, and pancreas. It is a member of the T-cell signaling pathway, which is a critical pathway involved in the regulation of immune and inflammatory responses. The T-cell signaling pathway is a complex process that involves the interaction between various proteins, including CHFR.

CHFR has been shown to play a role in the regulation of cell growth and differentiation. It has been shown to be involved in the development and maintenance of tissues, such as the liver and heart. CHFR has also been shown to be involved in the regulation of cellular processes, such as cell adhesion, migration, and survival.

CHFR and its potential uses as a drug target

CHFR has been shown to be a potential drug target in a variety of diseases. One of the main reasons for its potential as a drug target is its involvement in the regulation of the immune system. CHFR has been shown to play a role in the regulation of T-cell development and function, which is a critical component of the immune system.

CHFR has also been shown to play a role in the regulation of inflammation. It has been shown to be involved in the regulation of the production of pro-inflammatory cytokines, which can contribute to the development of inflammatory diseases.

CHFR has also been shown to be involved in the regulation of cell death. It has been shown to play a role in the regulation of apoptosis, which is a natural process that helps to remove damaged or dysfunctional cells from the body.

CHFR and its potential uses as a biomarker

CHFR has also been shown to be a potential biomarker for a variety of diseases. One of the main reasons for its potential as a biomarker is its involvement in the regulation of cellular processes, such as cell adhesion, migration, and survival. This makes it a potential biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

CHFR has also been shown to be involved in the regulation of inflammation. It has been shown to play a role in the regulation of the production of pro-inflammatory cytokines, which can contribute to the development of inflammatory diseases. This makes it a potential biomarker for a variety of inflammatory diseases, including rheumatoid arthritis, asthma, and chronic obstructive pulmonary disease (COPD).

CHFR has also been shown to be involved in the regulation of cell death. It has been shown to play a role in the regulation of apoptosis, which is a natural process that helps to remove damaged or dysfunctional cells from the body. This makes it a potential biomarker for a variety of diseases, including neurodegenerative diseases and cancer.

Conclusion

CHFR is a protein that is expressed in the liver and has been shown to play a role in the regulation of cell growth and differentiation, as well as the immune and inflammatory systems. As a result, CHFR is a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of CHFR in these processes and to develop new treatments based on its potential as a drug target or biomarker.

Protein Name: Checkpoint With Forkhead And Ring Finger Domains

Functions: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress

The "CHFR Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CHFR comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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